4L91

Crystal structure of Human Hsp90 with X29

Summary for 4L91

• Entry DOI: 10.2210/pdb4l91/pdb
• Related: 4L8Z 4L90 4L93 4L94
• Descriptor: Heat shock protein HSP 90-alpha, 4-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-chlorobenzene-1,3-diol (3 entities in total)
• Functional Keywords: atp hydrolysis, hsp90n-hsp90n inhibitor complex, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 25997.33

Authors

Li, J.,Ren, J.,Yang, M.,Xiong, B.,He, J. (deposition date: 2013-06-18, release date: 2014-06-18, Last modification date: 2023-11-08)

• Primary citation: Ren, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J.; Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization; Bioorg.Med.Chem.Lett., 24:2525-2529, 2014; PubMed: 24751441; DOI: 10.1016/j.bmcl.2014.03.100

Experimental method

X-RAY DIFFRACTION (1.75 Å)