4L94
Crystal structure of Human Hsp90 with S46
Summary for 4L94
Entry DOI | 10.2210/pdb4l94/pdb |
Related | 4L8Z 4L90 4L91 4L93 |
Descriptor | Heat shock protein HSP 90-alpha, (4-hydroxyphenyl)(4-methylpiperazin-1-yl)methanone (3 entities in total) |
Functional Keywords | atp hydrolysis, hsp90n-hsp90n inhibitor complex, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 25877.04 |
Authors | |
Primary citation | Ren, J.,Li, J.,Wang, Y.,Chen, W.,Shen, A.,Liu, H.,Chen, D.,Cao, D.,Li, Y.,Zhang, N.,Xu, Y.,Geng, M.,He, J.,Xiong, B.,Shen, J. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Bioorg.Med.Chem.Lett., 24:2525-2529, 2014 Cited by PubMed: 24751441DOI: 10.1016/j.bmcl.2014.03.100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.649 Å) |
Structure validation
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