Author results

4CMZ
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AN INTERTWINED HOMODIMER OF THE PDZ HOMOLOGY DOMAIN OF PERIAXIN
Descriptor:PERIAXIN
Authors:Han, H., Kursula, P.
Deposit date:2014-01-20
Release date:2014-04-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Periaxin and Ahnak Nucleoprotein 2 Form Intertwined Homodimers Through Domain Swapping
J.Biol.Chem., 289, 2014
4CN0
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AN INTERTWINED HOMODIMER OF THE PDZ HOMOLOGY DOMAIN OF AHNAK2
Descriptor:PROTEIN AHNAK2, TETRAETHYLENE GLYCOL, POTASSIUM ION
Authors:Han, H., Kursula, P.
Deposit date:2014-01-20
Release date:2014-04-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Periaxin and Ahnak Nucleoprotein 2 Form Intertwined Homodimers Through Domain Swapping
J.Biol.Chem., 289, 2014
4D77
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HIGH-RESOLUTION STRUCTURE OF THE EXTRACELLULAR OLFACTOMEDIN DOMAIN FROM GLIOMEDIN
Descriptor:GLIOMEDIN, SODIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Han, H., Kursula, P.
Deposit date:2014-11-20
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (1.481 Å)
Cite:The Olfactomedin Domain from Gliomedin is a Beta-Propeller with Unique Structural Properties.
J.Biol.Chem., 290, 2015
4D7C
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MONOCLINIC CRYSTAL FORM OF THE EXTRACELLULAR OLFACTOMEDIN DOMAIN FROM GLIOMEDIN
Descriptor:GLIOMEDIN, SODIUM ION
Authors:Han, H., Kursula, P.
Deposit date:2014-11-21
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Olfactomedin Domain from Gliomedin is a Beta-Propeller with Unique Structural Properties.
J.Biol.Chem., 290, 2015
6AP1
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VPS4P-VTA1P COMPLEX WITH PEPTIDE BINDING TO THE CENTRAL PORE OF VPS4P
Descriptor:Vacuolar protein sorting-associated protein 4,Protein hcp1, ACE-ASP-GLU-ILE-VAL-ASN-LYS-VAL-LEU-NH2, Vacuolar protein sorting-associated protein VTA1, ...
Authors:Han, H., Monroe, N., Shen, P., Sundquist, W.I., Hill, C.P.
Deposit date:2017-08-16
Release date:2017-12-06
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Elife, 6, 2017
6BMF
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VPS4P-VTA1P COMPLEX WITH PEPTIDE BINDING TO THE CENTRAL PORE OF VPS4P
Descriptor:Vacuolar protein sorting-associated protein 4, Vps2p, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Han, H., Monroe, N., Shen, P., Sundquist, W.I., Hill, C.P.
Deposit date:2017-11-14
Release date:2017-12-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
Elife, 6, 2017
2QDX
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P.AERUGINOSA FPR WITH FAD
Descriptor:Ferredoxin reductase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Han, H., Schonbrunn, E.
Deposit date:2007-06-21
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Biochemical and Structural Characterization of Pseudomonas aeruginosa Bfd and FPR: Ferredoxin NADP(+) Reductase and Not Ferredoxin Is the Redox Partner of Heme Oxygenase under Iron-Starvation Conditions
Biochemistry, 46, 2007
3CRZ
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FERREDOXIN-NADP REDUCTASE
Descriptor:Ferredoxin--NADP+ reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Han, H., Schonbrunn, E.
Deposit date:2008-04-08
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa
Biochemistry, 47, 2008
3PXY
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CDK2 IN COMPLEX WITH INHIBITOR JWS648
Descriptor:Cell division protein kinase 2, 2-(4,6-diamino-1,3,5-triazin-2-yl)-4-methoxyphenol, PHOSPHATE ION
Authors:Han, H., Betzi, S., Alam, R., Schonbrunn, E.
Deposit date:2010-12-10
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a Potential Allosteric Ligand Binding Site in CDK2.
Acs Chem.Biol., 6, 2011
3SWA
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E. CLOACAE MURA R120A COMPLEX WITH UNAG AND COVALENT ADDUCT OF PEP WITH CYS115
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, 1,2-ETHANEDIOL, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Han, H., Zhu, J.-Y., Schonbrunn, E.
Deposit date:2011-07-13
Release date:2012-03-07
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA).
J.Biol.Chem., 287, 2012
4EII
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UNLIGANDED E. CLOACAE R91K MURA
Descriptor:UDP-N-acetylglucosamine 1-carboxyvinyltransferase, GLYCEROL, 1,2-ETHANEDIOL, ...
Authors:Han, H., Zhu, J.-Y., Schonbrunn, E.
Deposit date:2012-04-05
Release date:2013-04-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Open-close transition of MurA
To be Published
4LCB
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STRUCTURE OF VPS4 HOMOLOG FROM ACIDIANUS HOSPITALIS
Descriptor:Cell division protein CdvC, Vps4, CHLORIDE ION
Authors:Han, H., Hill, C.P., Whitby, F.G., Monroe, N.
Deposit date:2013-06-21
Release date:2013-11-06
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:The Oligomeric State of the Active Vps4 AAA ATPase.
J.Mol.Biol., 426, 2014
4LGM
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CRYSTAL STRUCTURE OF SULFOLOBUS SOLFATARICUS VPS4
Descriptor:Vps4 AAA ATPase, CHLORIDE ION
Authors:Han, H., Hill, C.P., Whitby, F.G., Monroe, N.
Deposit date:2013-06-28
Release date:2013-11-06
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.711 Å)
Cite:The Oligomeric State of the Active Vps4 AAA ATPase.
J.Mol.Biol., 426, 2014
2PQ9
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E. COLI EPSPS LIGANDED WITH (R)-DIFLUOROMETHYL TETRAHEDRAL REACTION INTERMEDIATE ANALOG
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, (3R,4S,5R)-5-[(1R)-1-CARBOXY-2,2-DIFLUORO-1-(PHOSPHONOOXY)ETHOXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, FORMIC ACID
Authors:Healy-Fried, M.L., Funke, T., Han, H., Schonbrunn, E.
Deposit date:2007-05-01
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.
Biochemistry, 46, 2007
2PQB
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CP4 EPSPS LIGANDED WITH (R)-DIFLUOROMETHYL TETRAHEDRAL INTERMEDIATE ANALOG
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, (3R,4S,5R)-5-[(1R)-1-CARBOXY-2,2-DIFLUORO-1-(PHOSPHONOOXY)ETHOXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Authors:Healy-Fried, M.L., Funke, T., Han, H., Schonbrunn, E.
Deposit date:2007-05-01
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.
Biochemistry, 46, 2007
2PQC
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CP4 EPSPS LIGANDED WITH (R)-PHOSPHONATE TETRAHEDRAL REACTION INTERMEDIATE ANALOG
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, [3R-[3A,4A,5B(R*)]]-5-(1-CARBOXY-1-PHOSPHONOETHOXY)-4-HYDROXY-3-(PHOSPHONOOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID
Authors:Healy-Fried, M.L., Funke, T., Han, H., Schonbrunn, E.
Deposit date:2007-05-01
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.
Biochemistry, 46, 2007
2PQD
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A100G CP4 EPSPS LIGANDED WITH (R)-DIFLUOROMETHYL TETRAHEDRAL REACTION INTERMEDIATE ANALOG
Descriptor:3-phosphoshikimate 1-carboxyvinyltransferase, (3R,4S,5R)-5-[(1R)-1-CARBOXY-2,2-DIFLUORO-1-(PHOSPHONOOXY)ETHOXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Authors:Healy-Fried, M.L., Funke, T., Han, H., Schonbrunn, E.
Deposit date:2007-05-01
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues.
Biochemistry, 46, 2007
2YOZ
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CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, CRYSTALLIZED WITH 2'-AMPS
Descriptor:2,3-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, 2'-O-(sulfidophosphinato)adenosine, GLYCEROL, ...
Authors:Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.
Deposit date:2012-10-29
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
J.Mol.Biol., 425, 2013
2YP0
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CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, CRYSTALLIZED WITH 2'-AMPS
Descriptor:2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, 2'-O-(sulfidophosphinato)adenosine, ...
Authors:Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.
Deposit date:2012-10-29
Release date:2013-07-10
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
J.Mol.Biol., 425, 2013
2YPC
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CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, WITH MUTATION H309S, CRYSTALLIZED WITH 2',3-(SP)-CYCLIC-AMPS
Descriptor:2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, [(3aR,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-oxidanyl-2-sulfanylidene-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methanol
Authors:Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.
Deposit date:2012-10-30
Release date:2013-07-10
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.894 Å)
Cite:Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
J.Mol.Biol., 425, 2013
2YPE
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CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, WITH MUTATION H309S, CRYSTALLIZED WITH 2',3'- CYCLIC AMP
Descriptor:2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, ACETIC ACID, ...
Authors:Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.
Deposit date:2012-10-30
Release date:2013-07-10
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
J.Mol.Biol., 425, 2013
2YPH
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CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, WITH MUTATION H230S, CRYSTALLIZED WITH 2',3-(RP)- CYCLIC-AMPS
Descriptor:2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, ACETATE ION, ...
Authors:Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.
Deposit date:2012-10-30
Release date:2013-07-10
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
J.Mol.Biol., 425, 2013
2YQ9
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CATALYTIC DOMAIN OF MOUSE 2',3'-CYCLIC NUCLEOTIDE 3'- PHOSPHODIESTERASE, WITH MUTATION V321A, CRYSTALLIZED WITH 2'-AMP
Descriptor:2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, ADENOSINE-2'-MONOPHOSPHATE
Authors:Myllykoski, M., Raasakka, A., Lehtimaki, M., Han, H., Kursula, P.
Deposit date:2012-11-07
Release date:2013-07-10
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family
J.Mol.Biol., 425, 2013
3MFQ
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A GLANCE INTO THE METAL BINDING SPECIFICITY OF TROA: WHERE ELABORATE BEHAVIORS OCCUR IN THE ACTIVE CENTER
Descriptor:High-affinity zinc uptake system protein znuA, ZINC ION
Authors:Gao, G.F., Zheng, B., Zhang, Q., Gao, J., Han, H., Li, M.
Deposit date:2010-04-03
Release date:2011-04-13
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Insight into the interaction of metal ions with TroA from Streptococcus suis
Plos One, 6, 2011
3QL8
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CDK2 IN COMPLEX WITH INHIBITOR JWS-6-260
Descriptor:Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 3-(4-amino-1,3,5-triazin-2-yl)-4-hydroxybenzonitrile
Authors:Betzi, S., Alam, R., Han, H., Becker, A., Schonbrunn, E.
Deposit date:2011-02-02
Release date:2012-08-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
To be Published