4ZUD
Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution.
Summary for 4ZUD
Entry DOI | 10.2210/pdb4zud/pdb |
Descriptor | Chimera protein of Soluble cytochrome b562 and Type-1 angiotensin II receptor, Olmesartan (2 entities in total) |
Functional Keywords | human angiotensin receptor at1r, bril, g protein-coupled receptor, gpcr, gpcr network, lipidic cubic phase, lcp, membrane protein, structural genomics, olmesartan, angiotensin receptor blocker, anti-hypertensive drug, psi-biology, signaling protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 1 |
Total formula weight | 47168.54 |
Authors | Zhang, H.,Unal, H.,Desnoyer, R.,Han, G.W.,Patel, N.,Katritch, V.,Karnik, S.S.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2015-05-15, release date: 2015-10-07, Last modification date: 2023-09-27) |
Primary citation | Zhang, H.,Unal, H.,Desnoyer, R.,Han, G.W.,Patel, N.,Katritch, V.,Karnik, S.S.,Cherezov, V.,Stevens, R.C. Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J.Biol.Chem., 290:29127-29139, 2015 Cited by PubMed: 26420482DOI: 10.1074/jbc.M115.689000 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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