5GRM

Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)

Summary for 5GRM

DescriptorStimulator of interferon genes protein, cGAMP (3 entities in total)
Functional Keywordsrat sting, 2'3'-cgamp, immune system
Biological sourceRattus norvegicus (Rat)
Cellular locationEndoplasmic reticulum membrane ; Multi-pass membrane protein  F1M391
Total number of polymer chains2
Total molecular weight48546.24
Authors
Zhang, H.,Han, M.J.,Tao, J.L.,Ye, Z.Y.,Du, X.X.,Deng, M.J.,Zhang, X.Y.,Li, L.F.,Jiang, Z.F.,Su, X.D. (deposition date: 2016-08-11, release date: 2017-10-25)
Primary citation
Zhang, H.,Han, M.J.,Tao, J.L.,Ye, Z.Y.,Du, X.X.,Deng, M.J.,Zhang, X.Y.,Li, L.F.,Jiang, Z.F.,Su, X.D.
Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.55 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.193601.5%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5grm
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Molmil generated image of 5grm
rotated about x axis by 90°
Molmil generated image of 5grm
rotated about y axis by 90°