5GRM

Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Stimulator of interferon genes protein	polymer	210	23935.9	2	UniProt (F1M391) Pfam (PF15009)	Rattus norvegicus (Rat)	rSTING,Transmembrane protein 173
2	C (B)	cGAMP	non-polymer		674.4	1	Chemie (1SY)
3	D, E (A, B)	water	water		18.0	406	Chemie (HOH)

Sequence modifications

A, B: 155 - 341 (UniProt: F1M391)

PDB	External Database	Details
Met 132	-	expression tag
Gly 133	-	expression tag
Ser 134	-	expression tag
Ser 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
Ser 142	-	expression tag
Ser 143	-	expression tag
Gly 144	-	expression tag
Glu 145	-	expression tag
Asn 146	-	expression tag
Leu 147	-	expression tag
Tyr 148	-	expression tag
Phe 149	-	expression tag
Gln 150	-	expression tag
Gly 151	-	expression tag
Ser 152	-	expression tag
His 153	-	expression tag
Met 154	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47871.8
Non-Polymers*	Number of molecules	1
	Total formula weight	674.4
All*	Total formula weight	48546.2

*Water molecules are not included.