Author results

1G0U
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A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE
Descriptor:PROTEASOME COMPONENT Y7, PROTEASOME COMPONENT Y13, PROTEASOME COMPONENT PRE6, ...
Authors:Groll, M., Bajorek, M., Kohler, A., Moroder, L., Rubin, D.M., Huber, R., Glickman, M.H., Finley, D.
Deposit date:2000-10-09
Release date:2000-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A gated channel into the proteasome core particle.
Nat.Struct.Biol., 7, 2000
1RYP
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CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST AT 2.4 ANGSTROMS RESOLUTION
Descriptor:20S PROTEASOME, MAGNESIUM ION
Authors:Groll, M., Ditzel, L., Loewe, J., Stock, D., Bochtler, M., Bartunik, H.D., Huber, R.
Deposit date:1997-02-26
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of 20S proteasome from yeast at 2.4 A resolution.
Nature, 386, 1997
2GPL
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TMC-95 BASED BIPHENYL-ETHER MACROCYCLES: SPECIFIC PROTEASOME INHIBITORS
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Goetz, M., Kaiser, M., Weyher, E., Moroder, M.
Deposit date:2006-04-18
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome.
Chem.Biol., 13, 2006
2ZCY
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YEAST 20S PROTEASOME:SYRINGOLIN A-COMPLEX
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Dudler, R., Kaiser, M.
Deposit date:2007-11-15
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Nature, 452, 2008
3BDM
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YEAST 20S PROTEASOME:GLIDOBACTIN A-COMPLEX
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Dudler, R., Kaiser, M.
Deposit date:2007-11-15
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Nature, 452, 2008
3NZJ
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2A
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
Deposit date:2010-07-16
Release date:2011-02-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZW
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH 2B
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZX
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH LIGAND 2C
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
1G65
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CRYSTAL STRUCTURE OF EPOXOMICIN:20S PROTEASOME REVEALS A MOLECULAR BASIS FOR SELECTIVITY OF ALPHA,BETA-EPOXYKETONE PROTEASOME INHIBITORS
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Kim, K.B., Kairies, N., Huber, R., Crews, C.
Deposit date:2000-11-03
Release date:2000-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors
J.Am.Chem.Soc., 122, 2000
1J2P
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ALPHA-RING FROM THE PROTEASOME FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Proteasome alpha subunit
Authors:Groll, M., Brandstetter, H., Bartunik, H., Bourenkow, G., Huber, R.
Deposit date:2003-01-08
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1J2Q
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20S PROTEASOME IN COMPLEX WITH CALPAIN-INHIBITOR I FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Proteasome alpha subunit, Proteasome beta subunit, 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE
Authors:Groll, M., Brandstetter, H., Bartunik, H., Bourenkow, G., Huber, R.
Deposit date:2003-01-08
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1JD2
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME:TMC-95A COMPLEX: A NON-COVALENT PROTEASOME INHIBITOR
Descriptor:PROTEASOME COMPONENT Y7, PROTEASOME COMPONENT Y13, PROTEASOME COMPONENT PRE6, ...
Authors:Groll, M., Koguchi, Y., Huber, R., Kohno, J.
Deposit date:2001-06-12
Release date:2002-02-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.
J.Mol.Biol., 311, 2001
2F16
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH BORTEZOMIB
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M.
Deposit date:2005-11-14
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.
Structure, 14, 2006
2FAK
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CRYSTAL STRUCTURE OF SALINOSPORAMIDE A IN COMPLEX WITH THE YEAST 20S PROTEASOME
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Potts, B.C.
Deposit date:2005-12-07
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.
J.Am.Chem.Soc., 128, 2006
3DY3
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH THE EPIMER FORM OF SPIROLACTACYSTIN
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Balskus, E., Jacobsen, E.
Deposit date:2008-07-25
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130, 2008
3DY4
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CRYSTAL STRUCTURE OF YEAST 20S PROTEASOME IN COMPLEX WITH SPIROLACTACYSTIN
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Balskus, E., Jacobsen, E.
Deposit date:2008-07-25
Release date:2008-11-04
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130, 2008
3E47
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH HOMOBELACTOSIN C
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Larionov, O.V., de Meijere, A.
Deposit date:2008-08-10
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation
Proc.Natl.Acad.Sci.Usa, 103, 2006
3GPT
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH SALINOSPORAMIDE DERIVATIVES: SLOW SUBSTRATE LIGAND
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Macherla, V.R., Manam, R.R., Arthur, K.A.M., Potts, C.B.
Deposit date:2009-03-23
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
3GPW
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH SALINOSPORAMIDE DERIVATIVES: IRREVERSIBLE INHIBITOR LIGAND
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Macherla, V.R., Manam, R.R., Arthur, K.A.M., Potts, C.B.
Deposit date:2009-03-23
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
3HYE
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CRYSTAL STRUCTURE OF 20S PROTEASOME IN COMPLEX WITH HYDROXYLATED SALINOSPORAMIDE
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Arthur, K.A.M., Macherla, V.R., Manam, R.R., Potts, B.C.
Deposit date:2009-06-22
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
6GOP
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YEAST 20S PROTEASOME IN COMPLEX WITH HOMOSALINOSPORAMIDE A
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Groll, M., Romo, D.
Deposit date:2018-06-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study.
Mar Drugs, 16, 2018
3D29
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PROTEASOME INHIBITION BY FELLUTAMIDE B
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Hines, J., Fahnestock, M., Crews, M.C.
Deposit date:2008-05-07
Release date:2008-06-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis
Chem.Biol., 15, 2008
3GPJ
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CRYSTAL STRUCTURE OF THE YEAST 20S PROTEASOME IN COMPLEX WITH SYRINGOLIN B
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Huber, R., Kaiser, M.
Deposit date:2009-03-23
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
Proc.Natl.Acad.Sci.USA, 106, 2009
3OKJ
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ALPHA-KETO-ALDEHYDE BINDING MECHANISM REVEALS A NOVEL LEAD STRUCTURE MOTIF FOR PROTEASOME INHIBITION
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Groll, M., Poynor, M., Gallastegui, P., Stein, M., Schmidt, B., Kloetzel, P.M., Huber, R.
Deposit date:2010-08-25
Release date:2011-06-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition
Angew.Chem.Int.Ed.Engl., 50, 2011
5NRT
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CYS-GLY DIPEPTIDASE GLIJ IN COMPLEX WITH CA2+
Descriptor:Dipeptidase gliJ, CALCIUM ION, MAGNESIUM ION
Authors:Groll, M., Huber, E.M.
Deposit date:2017-04-25
Release date:2017-05-31
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017