3GPT

Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow substrate ligand

Summary for 3GPT

Entry DOI	10.2210/pdb3gpt/pdb
Related	1ryp 2fak 3GPJ 3GPW
Descriptor	Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywords	proteasome, ubiquitin, cancer therapy, inhibitor, immunology, time dependent leaving group elimination, cytoplasm, hydrolase, nucleus, phosphoprotein, protease, threonine protease, isopeptide bond, ubl conjugation, zymogen
Biological source	Saccharomyces cerevisiae (yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	706002.27
Authors	Groll, M.,Macherla, V.R.,Manam, R.R.,Arthur, K.A.M.,Potts, C.B. (deposition date: 2009-03-23, release date: 2009-09-15, Last modification date: 2023-09-06)
Primary citation	Groll, M.,McArthur, K.A.,Macherla, V.R.,Manam, R.R.,Potts, B.C. Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition J.Med.Chem., 52:5420-5428, 2009 Cited by PubMed: 19678642 DOI: 10.1021/jm900559x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation