3GPJ

Crystal structure of the yeast 20S proteasome in complex with syringolin B

Summary for 3GPJ

Entry DOI	10.2210/pdb3gpj/pdb
Related	1ryp 2ZCY 3BDM 3GPT 3GPW
Descriptor	Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywords	proteasome, virulence, ubiquitin, cancer therapy, immunology, cytoplasm, hydrolase, nucleus, phosphoprotein, protease, threonine protease, isopeptide bond, ubl conjugation, zymogen
Biological source	Saccharomyces cerevisiae (yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	706188.69
Authors	Groll, M.,Huber, R.,Kaiser, M. (deposition date: 2009-03-23, release date: 2009-06-02, Last modification date: 2023-09-06)
Primary citation	Clerc, J.,Groll, M.,Illich, D.J.,Bachmann, A.S.,Huber, R.,Schellenberg, B.,Dudler, R.,Kaiser, M. Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition Proc.Natl.Acad.Sci.USA, 106:6507-6512, 2009 Cited by PubMed: 19359491 DOI: 10.1073/pnas.0901982106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation