3NZX

Crystal structure of the yeast 20S proteasome in complex with ligand 2c

Summary for 3NZX

Related1JD2 1RYP 3NZJ 3NZW
Related PRD IDPRD_001105
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (16 entities in total)
Functional Keywordsubiquitin, protein degradation, n-terminal nucleophilic hydrolase, 19s regulatory particle, ubiquitin-tagged substrates, cytosol, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains30
Total molecular weight768307.84
Authors
Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, M.,Vidal, V.,Reboud-Ravaux, M. (deposition date: 2010-07-17, release date: 2011-02-16, Last modification date: 2012-12-12)
Primary citation
Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, L.,Vidal, J.,Reboud-Ravaux, M.
20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5:1701-1705, 2010
PubMed: 20715286 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201000293
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.226181.1%6.5%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3nzx
no rotation
Molmil generated image of 3nzx
rotated about x axis by 90°
Molmil generated image of 3nzx
rotated about y axis by 90°