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3NZX

Crystal structure of the yeast 20S proteasome in complex with ligand 2c

Summary for 3NZX
Entry DOI10.2210/pdb3nzx/pdb
Related1JD2 1RYP 3NZJ 3NZW
Related PRD IDPRD_001105
DescriptorProteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywordsubiquitin, protein degradation, n-terminal nucleophilic hydrolase, 19s regulatory particle, ubiquitin-tagged substrates, cytosol, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast)
More
Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains30
Total formula weight768307.84
Authors
Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, M.,Vidal, V.,Reboud-Ravaux, M. (deposition date: 2010-07-17, release date: 2011-02-16, Last modification date: 2023-12-06)
Primary citationGroll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, L.,Vidal, J.,Reboud-Ravaux, M.
20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5:1701-1705, 2010
Cited by
PubMed: 20715286
DOI: 10.1002/cmdc.201000293
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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