Yeast 20S Proteasome in complex with Homosalinosporamide A

Summary for 6GOP

Related5CZ4 2FAK
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (18 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, natural product, proteasome, inhibitor, binding analysis, hydrolase
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Total number of polymer chains28
Total molecular weight733341.63
Groll, M.,Romo, D. (deposition date: 2018-06-01, release date: 2018-08-01)
Primary citation
Groll, M.,Nguyen, H.,Vellalath, S.,Romo, D.
(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study.
Mar Drugs, 16:-, 2018
PubMed: 30029468 (PDB entries with the same primary citation)
DOI: 10.3390/md16070240
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23910.3%3.1%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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