Author results

3IXT
  • Download 3ixt
  • View 3ixt
Molmil generated image of 3ixt
CRYSTAL STRUCTURE OF MOTAVIZUMAB FAB BOUND TO PEPTIDE EPITOPE
Descriptor:Motavizumab Fab light chain, Motavizumab Fab heavy chain, Fusion glycoprotein F1, ...
Authors:McLellan, J.S., Chen, M., Kim, A., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2009-09-04
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis of respiratory syncytial virus neutralization by motavizumab.
Nat.Struct.Mol.Biol., 17, 2010
3O41
  • Download 3o41
  • View 3o41
Molmil generated image of 3o41
CRYSTAL STRUCTURE OF 101F FAB BOUND TO 15-MER PEPTIDE EPITOPE
Descriptor:Mouse monoclonal antibody 101F Fab light chain, Mouse monoclonal antibody 101F Fab heavy chain, Fusion glycoprotein F1, ...
Authors:McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D.
Deposit date:2010-07-26
Release date:2010-10-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F.
J.Virol., 84, 2010
3O45
  • Download 3o45
  • View 3o45
Molmil generated image of 3o45
CRYSTAL STRUCTURE OF 101F FAB BOUND TO 17-MER PEPTIDE EPITOPE
Descriptor:Mouse monoclonal antibody 101F 101F Fab light chain, Mouse monoclonal antibody 101F 101F Fab heavy chain, Fusion glycoprotein F1, ...
Authors:McLellan, J.S., Chen, M., Chang, J.S., Yang, Y., Kim, A., Graham, B.S., Kwong, P.D.
Deposit date:2010-07-26
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.872 Å)
Cite:Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F.
J.Virol., 84, 2010
3RRR
  • Download 3rrr
  • View 3rrr
Molmil generated image of 3rrr
STRUCTURE OF THE RSV F PROTEIN IN THE POST-FUSION CONFORMATION
Descriptor:Fusion glycoprotein F0, N-ACETYL-D-GLUCOSAMINE
Authors:McLellan, J.S., Yongping, Y., Graham, B.S., Kwong, P.D.
Deposit date:2011-04-30
Release date:2011-06-08
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.821 Å)
Cite:Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
J.Virol., 85, 2011
3RRT
  • Download 3rrt
  • View 3rrt
Molmil generated image of 3rrt
STRUCTURE OF THE RSV F PROTEIN IN THE POST-FUSION CONFORMATION
Descriptor:Fusion glycoprotein F0
Authors:McLellan, J.S., Yongping, Y., Graham, B.S., Kwong, P.D.
Deposit date:2011-04-30
Release date:2011-06-08
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
J.Virol., 85, 2011
4JHA
  • Download 4jha
  • View 4jha
Molmil generated image of 4jha
CRYSTAL STRUCTURE OF RSV-NEUTRALIZING HUMAN ANTIBODY D25
Descriptor:D25 antigen-binding fragment heavy chain, D25 light chain
Authors:Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S.
Deposit date:2013-03-04
Release date:2013-05-01
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
4JHW
  • Download 4jhw
  • View 4jhw
Molmil generated image of 4jhw
CRYSTAL STRUCTURE OF RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN STABILIZED IN THE PREFUSION CONFORMATION BY HUMAN ANTIBODY D25
Descriptor:D25 antigen-binding fragment heavy chain, D25 light chain, Fusion glycoprotein F0
Authors:Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S.
Deposit date:2013-03-05
Release date:2013-05-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
4MMQ
  • Download 4mmq
  • View 4mmq
Molmil generated image of 4mmq
CRYSTAL STRUCTURE OF PREFUSION-STABILIZED RSV F VARIANT DS
Descriptor:Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain, SULFATE ION
Authors:Mclellan, J.S., Joyce, M.G., Stewart-Jones, G.B.E., Sastry, M., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.253 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
4MMR
  • Download 4mmr
  • View 4mmr
Molmil generated image of 4mmr
CRYSTAL STRUCTURE OF PREFUSION-STABILIZED RSV F VARIANT CAV1 AT PH 9.5
Descriptor:Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain
Authors:Stewart-Jones, G.B.E., McLellan, J.S., Joyce, M.G., Sastry, M., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
4MMS
  • Download 4mms
  • View 4mms
Molmil generated image of 4mms
CRYSTAL STRUCTURE OF PREFUSION-STABILIZED RSV F VARIANT CAV1 AT PH 5.5
Descriptor:Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain, SULFATE ION
Authors:Mclellan, J.S., Joyce, M.G., Stewart-Jones, G.B.E., Sastry, M., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
4MMT
  • Download 4mmt
  • View 4mmt
Molmil generated image of 4mmt
CRYSTAL STRUCTURE OF PREFUSION-STABILIZED RSV F VARIANT DS-CAV1 AT PH 9.5
Descriptor:Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain
Authors:Joyce, M.G., Mclellan, J.S., Stewart-Jones, G.B.E., Sastry, M., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
4MMU
  • Download 4mmu
  • View 4mmu
Molmil generated image of 4mmu
CRYSTAL STRUCTURE OF PREFUSION-STABILIZED RSV F VARIANT DS-CAV1 AT PH 5.5
Descriptor:Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain, SULFATE ION, ...
Authors:Joyce, M.G., Mclellan, J.S., Stewart-Jones, G.B.E., Sastry, M., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
4MMV
  • Download 4mmv
  • View 4mmv
Molmil generated image of 4mmv
CRYSTAL STRUCTURE OF PREFUSION-STABILIZED RSV F VARIANT DS-CAV1-TRIC AT PH 9.5
Descriptor:Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain
Authors:Stewart-Jones, G.B.E., McLellan, J.S., Joyce, M.G., Sastry, M., Yang, Y., Graham, B.S., Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
4ZPV
  • Download 4zpv
  • View 4zpv
Molmil generated image of 4zpv
STRUCTURE OF MERS-CORONAVIRUS SPIKE RECEPTOR-BINDING DOMAIN (ENGLAND1 STRAIN) IN COMPLEX WITH VACCINE-ELICITED MURINE NEUTRALIZING ANTIBODY D12 (CRYSTAL FORM 2)
Descriptor:D12 Fab Heavy chain, D12 Fab light chain, Spike glycoprotein, ...
Authors:Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D.
Deposit date:2015-05-08
Release date:2015-10-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Evaluation of candidate vaccine approaches for MERS-CoV.
Nat Commun, 6, 2015
4ZPW
  • Download 4zpw
  • View 4zpw
Molmil generated image of 4zpw
STRUCTURE OF UNBOUND MERS-COV SPIKE RECEPTOR-BINDING DOMAIN (ENGLAND1 STRAIN).
Descriptor:Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE, PHOSPHATE ION
Authors:Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D.
Deposit date:2015-05-08
Release date:2015-08-12
Method:X-RAY DIFFRACTION (3.023 Å)
Cite:Evaluation of candidate vaccine approaches for MERS-CoV.
Nat Commun, 6, 2015
5I08
  • Download 5i08
  • View 5i08
Molmil generated image of 5i08
PREFUSION STRUCTURE OF A HUMAN CORONAVIRUS SPIKE PROTEIN
Descriptor:Spike glycoprotein, envelope glycoprotein chimera
Authors:Kirchdoerfer, R.N., Cottrell, C.A., Wang, N., Pallesen, J., Yassine, H.M., Turner, H.L., Corbett, K.S., Graham, B.S., McLellan, J.S., Ward, A.B.
Deposit date:2016-02-03
Release date:2016-03-02
Last modified:2016-04-13
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Pre-fusion structure of a human coronavirus spike protein.
Nature, 531, 2016
5TR8
  • Download 5tr8
  • View 5tr8
Molmil generated image of 5tr8
CRYSTAL STRUCTURE OF VACCINE-ELICITED PAN- INFLUENZA H1N1 NEUTRALIZING MURINE ANTIBODY 441D6.
Descriptor:441D6 Fab Light chain, 441D6 Fab Heavy chain, NICKEL (II) ION
Authors:Joyce, M.G., Kanekiyo, M., Mascola, J.R., Graham, B.S., Kwong, P.D.
Deposit date:2016-10-25
Release date:2018-05-09
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of vaccine-elicited pan- influenza H1N1 neutralizing murine antibody 441D6.
To Be Published
6C6X
  • Download 6c6x
  • View 6c6x
Molmil generated image of 6c6x
CRYSTAL STRUCTURE OF MIDDLE-EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS NEUTRALIZING ANTIBODY JC57-14 ISOLATED FROM A VACCINATED RHESUS MACAQUE.
Descriptor:JC57-14 Heavy chain, JC57-14 Light chain
Authors:Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D.
Deposit date:2018-01-19
Release date:2018-02-28
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
6C6Y
  • Download 6c6y
  • View 6c6y
Molmil generated image of 6c6y
CRYSTAL STRUCTURE OF MIDDLE-EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS NEUTRALIZING ANTIBODY JC57-14 ISOLATED FROM A VACCINATED RHESUS MACAQUE IN COMPLEX WITH MERS RECEPTOR BINDING DOMAIN
Descriptor:JC57-14 Heavy chain, JC57-14 Light chain, Spike glycoprotein, ...
Authors:Joyce, M.G., Mascola, J.R., Graham, B.S., Kwong, P.D.
Deposit date:2018-01-19
Release date:2018-03-07
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
3QWO
  • Download 3qwo
  • View 3qwo
Molmil generated image of 3qwo
CRYSTAL STRUCTURE OF A MOTAVIZUMAB EPITOPE-SCAFFOLD BOUND TO MOTAVIZUMAB FAB
Descriptor:motavizumab light chain, motavizumab heavy chain, motavizumab epitope scaffold, ...
Authors:McLellan, J.S., Kwong, P.D.
Deposit date:2011-02-28
Release date:2011-05-04
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus.
J.Mol.Biol., 409, 2011
4JLR
  • Download 4jlr
  • View 4jlr
Molmil generated image of 4jlr
CRYSTAL STRUCTURE OF A DESIGNED RESPIRATORY SYNCYTIAL VIRUS IMMUNOGEN IN COMPLEX WITH MOTAVIZUMAB
Descriptor:Motavizumab Fab heavy chain, Motavizumab Fab light chain, RSV_1Isea designed scaffold, ...
Authors:Rupert, P.B., Correia, B., Schief, W., Strong, R.K.
Deposit date:2013-03-12
Release date:2014-02-05
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
4L8I
  • Download 4l8i
  • View 4l8i
Molmil generated image of 4l8i
CRYSTAL STRUCTURE OF RSV EPITOPE SCAFFOLD FFL_005
Descriptor:RSV epitope scaffold FFL_005
Authors:Jardine, J., Correnti, C., Holmes, M.A., Strong, R.K., Schief, W.R.
Deposit date:2013-06-17
Release date:2014-02-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
4N9G
  • Download 4n9g
  • View 4n9g
Molmil generated image of 4n9g
CRYSTAL STRUCTURE OF A COMPUTATIONALLY DESIGNED RSV-PRESENTING EPITOPE SCAFFOLD AND ITS ELICITED ANTIBODY 17HD9
Descriptor:Antibody 17HD9, Heavy Chain, Light Chain, ...
Authors:Carrico, C.T.D., Strong, R.K.
Deposit date:2013-10-21
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
4OLU
  • Download 4olu
  • View 4olu
Molmil generated image of 4olu
CRYSTAL STRUCTURE OF ANTIBODY VRC07 IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OLV
  • Download 4olv
  • View 4olv
Molmil generated image of 4olv
CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54F IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014