4ZPV
Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2)
Summary for 4ZPV
Entry DOI | 10.2210/pdb4zpv/pdb |
Related | 4ZPT 4ZPW |
Descriptor | D12 Fab Heavy chain, D12 Fab light chain, Spike glycoprotein, ... (4 entities in total) |
Functional Keywords | vaccine, immunogen, viral protein-immune system complex, viral protein/immune system |
Biological source | Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) More |
Cellular location | Spike protein S2: Virion membrane ; Single-pass type I membrane protein . Spike protein S1: Virion membrane ; Peripheral membrane protein : K9N5Q8 |
Total number of polymer chains | 6 |
Total formula weight | 140092.24 |
Authors | Joyce, M.G.,Mascola, J.R.,Graham, B.S.,Kwong, P.D. (deposition date: 2015-05-08, release date: 2015-10-21, Last modification date: 2020-07-29) |
Primary citation | Wang, L.,Shi, W.,Joyce, M.G.,Modjarrad, K.,Zhang, Y.,Leung, K.,Lees, C.R.,Zhou, T.,Yassine, H.M.,Kanekiyo, M.,Yang, Z.Y.,Chen, X.,Becker, M.M.,Freeman, M.,Vogel, L.,Johnson, J.C.,Olinger, G.,Todd, J.P.,Bagci, U.,Solomon, J.,Mollura, D.J.,Hensley, L.,Jahrling, P.,Denison, M.R.,Rao, S.S.,Subbarao, K.,Kwong, P.D.,Mascola, J.R.,Kong, W.P.,Graham, B.S. Evaluation of candidate vaccine approaches for MERS-CoV. Nat Commun, 6:7712-7712, 2015 Cited by PubMed: 26218507DOI: 10.1038/ncomms8712 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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