4ZPV

Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2)

Summary for 4ZPV

• Entry DOI: 10.2210/pdb4zpv/pdb
• Related: 4ZPT 4ZPW
• Descriptor: D12 Fab Heavy chain, D12 Fab light chain, Spike glycoprotein, ... (4 entities in total)
• Functional Keywords: vaccine, immunogen, viral protein-immune system complex, viral protein/immune system
• Biological source: Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC); More
• Cellular location: Spike protein S2: Virion membrane ; Single-pass type I membrane protein . Spike protein S1: Virion membrane ; Peripheral membrane protein : K9N5Q8
• Total number of polymer chains: 6
• Total formula weight: 140092.24

Authors

Joyce, M.G.,Mascola, J.R.,Graham, B.S.,Kwong, P.D. (deposition date: 2015-05-08, release date: 2015-10-21, Last modification date: 2020-07-29)

• Primary citation: Wang, L.,Shi, W.,Joyce, M.G.,Modjarrad, K.,Zhang, Y.,Leung, K.,Lees, C.R.,Zhou, T.,Yassine, H.M.,Kanekiyo, M.,Yang, Z.Y.,Chen, X.,Becker, M.M.,Freeman, M.,Vogel, L.,Johnson, J.C.,Olinger, G.,Todd, J.P.,Bagci, U.,Solomon, J.,Mollura, D.J.,Hensley, L.,Jahrling, P.,Denison, M.R.,Rao, S.S.,Subbarao, K.,Kwong, P.D.,Mascola, J.R.,Kong, W.P.,Graham, B.S.; Evaluation of candidate vaccine approaches for MERS-CoV.; Nat Commun, 6:7712-7712, 2015; PubMed: 26218507; DOI: 10.1038/ncomms8712

Experimental method

X-RAY DIFFRACTION (3.2 Å)