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4KSB
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.8001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSC
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KSD
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STRUCTURES OF P-GLYCOPROTEIN REVEAL ITS CONFORMATIONAL FLEXIBILITY AND AN EPITOPE ON THE NUCLEOTIDE-BINDING DOMAIN
Descriptor:Multidrug resistance protein 1A, R2 protein
Authors:Ward, A., Szewczyk, P., Grimard, V., Lee, C.-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.
Deposit date:2013-05-17
Release date:2013-07-31
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (4.1001 Å)
Cite:Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110, 2013
6HJX
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) 7'C PORE MUTANT (L238C) IN COMPLEX WITH NANOBODY 72
Descriptor:Cys-loop ligand-gated ion channel, nanobody 72, HEXAETHYLENE GLYCOL, ...
Authors:Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HJY
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) DELTA8 TRUNCATION MUTANT IN COMPLEX WITH NANOBODY 72
Descriptor:Cys-loop ligand-gated ion channel, nanobody 72
Authors:Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HK0
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) F16'S PORE MUTANT (F247S) WITH ALTERNATE M4 CONFORMATION.
Descriptor:Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE
Authors:Nury, H., Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6SSI
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STRUCTURE OF THE PENTAMERIC LIGAND-GATED ION CHANNEL ELIC IN COMPLEX WITH A PAM NANOBODY
Descriptor:Cys-loop ligand-gated ion channel, NANOBODY 22, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J.
Deposit date:2019-09-07
Release date:2020-02-12
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Modulation of theErwinialigand-gated ion channel (ELIC) and the 5-HT3receptor via a common vestibule site.
Elife, 9, 2020
6SSP
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STRUCTURE OF THE PENTAMERIC LIGAND-GATED ION CHANNEL ELIC IN COMPLEX WITH A NAM NANOBODY
Descriptor:Cys-loop ligand-gated ion channel, NANOBODY 21, CALCIUM ION, ...
Authors:Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J.
Deposit date:2019-09-09
Release date:2020-02-12
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Modulation of theErwinialigand-gated ion channel (ELIC) and the 5-HT3receptor via a common vestibule site.
Elife, 9, 2020
6GJQ
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODY T27
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody T27, ADENOSINE-5'-TRIPHOSPHATE
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-16
Release date:2019-06-19
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GJS
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND T4
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody T4, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-16
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GJU
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES T2A AND T4
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody T4, Nanobody T2a, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-17
Release date:2019-06-26
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GK4
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND T8
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody T8, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-18
Release date:2019-06-19
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GKD
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND G3A
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody G3a, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-18
Release date:2019-06-19
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
3LNN
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CRYSTAL STRUCTURE OF ZNEB FROM CUPRIAVIDUS METALLIDURANS
Descriptor:Membrane fusion protein (MFP) heavy metal cation efflux ZneB (CzcB-like), ZINC ION
Authors:Lee, J.K., De Angelis, F., Miercke, L.J., Stroud, R.M., Vandenbussche, G., Center for Structures of Membrane Proteins (CSMP)
Deposit date:2010-02-02
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems.
Proc.Natl.Acad.Sci.USA, 107, 2010