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1AP8
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BU of 1ap8 by Molmil
TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, TRANSLATION INITIATION FACTOR EIF4E
Authors:Matsuo, H, Li, H, Mcguire, A.M, Fletcher, M, Gingras, A.C, Sonenberg, N, Wagner, G.
Deposit date:1997-07-25
Release date:1998-01-28
Last modified:2024-03-06
Method:SOLUTION NMR
Cite:Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
Nat.Struct.Biol., 4, 1997
1L8B
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BU of 1l8b by Molmil
Cocrystal Structure of the Messenger RNA 5' Cap-binding Protein (eIF4E) bound to 7-methylGpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
Authors:Niedzwiecka, A, Marcotrigiano, J, Stepinski, J, Jankowska-Anyszka, M, Wyslouch-Cieszynska, A, Dadlez, M, Gingras, A.-C, Mak, P, Darzynkiewicz, E, Sonenberg, N.
Deposit date:2002-03-19
Release date:2002-06-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
J.Mol.Biol., 319, 2002
7VKI
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BU of 7vki by Molmil
ESRP1 qRRM2 in complex with 12mer-RNA
Descriptor: Epithelial splicing regulatory protein 1, RNA (12-mer)
Authors:Wu, B.X, Patel, D.J.
Deposit date:2021-09-30
Release date:2022-10-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
Nucleic Acids Res., 2023
6F9S
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BU of 6f9s by Molmil
Crystal structure of the C-terminal RecA domain of DDX6 in complex with a conserved peptide from LSM14
Descriptor: Cytokinesis, Apoptosis, RNA-associated, ...
Authors:Jinek, M, Brandmann, T.
Deposit date:2017-12-15
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6F9W
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BU of 6f9w by Molmil
Crystal structure of the LSM domain of LSM14 in complex with a C-terminal peptide of 4E-T
Descriptor: Eukaryotic translation initiation factor 4E transporter, Protein LSM14 homolog A
Authors:Brandmann, T, Jinek, M.
Deposit date:2017-12-15
Release date:2018-03-21
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6FDL
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BU of 6fdl by Molmil
Crystal structure of the NYN domain of human MARF1
Descriptor: Meiosis regulator and mRNA stability factor 1
Authors:Jinek, M, Brandmann, T.
Deposit date:2017-12-26
Release date:2018-11-07
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
6AMB
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BU of 6amb by Molmil
Crystal Structure of the Afadin RA1 domain in complex with HRAS
Descriptor: Afadin, GTPase HRas, MAGNESIUM ION, ...
Authors:Smith, M.J, Ishiyama, N, Ikura, M.
Deposit date:2017-08-09
Release date:2017-11-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
Nat Commun, 8, 2017
3LXJ
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BU of 3lxj by Molmil
Crystal Structure of the Bromodomain of Human AAA domain containing 2B (ATAD2B)
Descriptor: ATPase family AAA domain-containing protein 2B, ISOPROPYL ALCOHOL
Authors:Filippakopoulos, P, Keates, T, Picaud, S, Fedorov, O, Krojer, T, Vollmar, M, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-02-25
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2RFJ
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BU of 2rfj by Molmil
Crystal structure of the bromo domain 1 in human bromodomain containing protein, testis specific (BRDT)
Descriptor: Bromodomain testis-specific protein
Authors:Filippakopoulos, P, Salah, E, Savitsky, P, Keates, T, Parizotto, E, Elkins, J, Pike, A.C.W, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Sundstrom, M, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2007-09-30
Release date:2007-10-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
6G0P
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BU of 6g0p by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Transcription factor E2F1
Authors:Filippakopoulos, P, Picaud, S, Krojer, T, Sorrell, F, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0R
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BU of 6g0r by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated POLR2A peptide (K775ac/K778ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DNA-directed RNA polymerase II subunit RPB1
Authors:Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NNC
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BU of 5nnc by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
Descriptor: Bromodomain-containing protein 4, Histone H3
Authors:Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
5NND
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BU of 5nnd by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Histone H3
Authors:Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2017-04-08
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
3MB4
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BU of 3mb4 by Molmil
Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP
Descriptor: 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, CHLORIDE ION, ...
Authors:Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MQM
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BU of 3mqm by Molmil
Crystal Structure of the Bromodomain of human ASH1L
Descriptor: Probable histone-lysine N-methyltransferase ASH1L
Authors:Filippakopoulos, P, Picaud, S, Keates, T, Felletar, I, Vollmar, M, Chaikuad, A, Krojer, T, Canning, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-04-28
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MB3
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BU of 3mb3 by Molmil
Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP)
Descriptor: 1-methylpyrrolidin-2-one, PH-interacting protein
Authors:Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
6BXI
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BU of 6bxi by Molmil
X-ray crystal structure of NDR1 kinase domain
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase 38
Authors:Xiong, S, Sicheri, F.
Deposit date:2017-12-18
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Structure, 26, 2018
6DRM
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BU of 6drm by Molmil
OTU domain of Fam105A
Descriptor: Inactive ubiquitin thioesterase FAM105A
Authors:Ceccarelli, D.F, Sicheri, F, Cordes, S.
Deposit date:2018-06-12
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.
Structure, 27, 2019
4ZX2
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BU of 4zx2 by Molmil
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Descriptor: (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E.
Deposit date:2015-05-19
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
4ZVZ
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BU of 4zvz by Molmil
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Descriptor: (1R,2S,3R,4S,5S)-5-(propoxymethyl)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ...
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E.
Deposit date:2015-05-18
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
6G0S
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BU of 6g0s by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SIRT7 peptide (K272ac/K275ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, NAD-dependent protein deacetylase sirtuin-7
Authors:Filippakopoulos, P, Picaud, S, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0O
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BU of 6g0o by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated ATRX peptide (K1030ac/K1033ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Transcriptional regulator ATRX
Authors:Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6G0Q
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BU of 6g0q by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated GATA1 peptide (K312ac/K315ac)
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Erythroid transcription factor
Authors:Filippakopoulos, P, Picaud, S, Newman, J, Sorrell, F, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
Deposit date:2018-03-19
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
6OGN
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BU of 6ogn by Molmil
Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe
Descriptor: 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine, Protein arginine N-methyltransferase 7, UNKNOWN ATOM OR ION, ...
Authors:Halabelian, L, Dong, A, Zeng, H, Li, Y, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2019-04-03
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Nat Commun, 11, 2020
8TTQ
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BU of 8ttq by Molmil
Cryo-EM structure of the inner MKLN1 dimer from an autoinhibited MKLN1 tetramer
Descriptor: Muskelin
Authors:Chana, C.K, Keszei, A.F.A, Sicheri, F.
Deposit date:2023-08-14
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.
Nat Commun, 15, 2024

 

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