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6AMB

Crystal Structure of the Afadin RA1 domain in complex with HRAS

Summary for 6AMB
Entry DOI10.2210/pdb6amb/pdb
DescriptorGTPase HRas, Afadin, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
Functional Keywordsgtpase, adhesion, ra domain, rbd domain, signaling protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane. Isoform 2: Nucleus: P01112
Cell junction, adherens junction: Q9QZQ1
Total number of polymer chains2
Total formula weight31462.41
Authors
Smith, M.J.,Ishiyama, N.,Ikura, M. (deposition date: 2017-08-09, release date: 2017-11-01, Last modification date: 2023-10-04)
Primary citationSmith, M.J.,Ottoni, E.,Ishiyama, N.,Goudreault, M.,Haman, A.,Meyer, C.,Tucholska, M.,Gasmi-Seabrook, G.,Menezes, S.,Laister, R.C.,Minden, M.D.,Marschalek, R.,Gingras, A.C.,Hoang, T.,Ikura, M.
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
Nat Commun, 8:1099-1099, 2017
Cited by
PubMed: 29062045
DOI: 10.1038/s41467-017-01326-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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