6G0P
Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated E2F1 peptide (K117ac/K120ac)
Summary for 6G0P
Entry DOI | 10.2210/pdb6g0p/pdb |
Descriptor | Bromodomain-containing protein 4, Transcription factor E2F1, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, transcription, complex |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 17004.47 |
Authors | Filippakopoulos, P.,Picaud, S.,Krojer, T.,Sorrell, F.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C. (deposition date: 2018-03-19, release date: 2018-11-28, Last modification date: 2024-01-17) |
Primary citation | Lambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73:621-638.e17, 2019 Cited by PubMed: 30554943DOI: 10.1016/j.molcel.2018.11.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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