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5EX0
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CRYSTAL STRUCTURE OF HUMAN SMYD3 IN COMPLEX WITH A MAP3K2 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase SMYD3, MAP3K2 peptide, ZINC ION, ...
Authors:Fu, W., Liu, N., Qiao, Q., Wang, M., Min, J., Zhu, B., Xu, R.M., Yang, N.
Deposit date:2015-11-23
Release date:2016-03-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase
J.Biol.Chem., 291, 2016
2JSO
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ANTIMICROBIAL RESISTANCE PROTEIN
Descriptor:Polymyxin resistance protein pmrD
Authors:Jin, C., Fu, W.
Deposit date:2007-07-10
Release date:2007-09-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:First structure of the polymyxin resistance proteins.
Biochem.Biophys.Res.Commun., 361, 2007
5EX3
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CRYSTAL STRUCTURE OF HUMAN SMYD3 IN COMPLEX WITH A VEGFR1 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase SMYD3, VEGFR1 peptide, ZINC ION, ...
Authors:Qiao, Q., Fu, W., Liu, N., Wang, M., Min, J., Zhu, B., Xu, R.M., Yang, N.
Deposit date:2015-11-23
Release date:2016-03-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase
J.Biol.Chem., 291, 2016
2W6C
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ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE
Descriptor:ACETYLCHOLINESTERASE, 3-[(3R)-3-ethyl-1-{9-[(3S)-3-ethyl-3-(3-hydroxyphenyl)azepan-1-yl]nonyl}azepan-3-yl]phenol, N-ACETYL-D-GLUCOSAMINE
Authors:Paz, A., Xie, Q., Greenblatt, H.M., Fu, W., Tang, Y., Silman, I., Qiu, Z., Sussman, J.L.
Deposit date:2008-12-18
Release date:2009-04-07
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(-)-Nor-Meptazinol Derivative Reveals Disruption of the Catalytic Triad.
J.Med.Chem., 52, 2009
1TX7
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BOVINE TRYPSIN COMPLEXED WITH P-AMIDINOPHENYLMETHYLPHOSPHINIC ACID (AMPA)
Descriptor:Trypsinogen, CALCIUM ION, (4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC ACID
Authors:Cui, J., Marankan, F., Fu, W., Crich, D., Mesecar, A., Johnson, M.E.
Deposit date:2004-07-02
Release date:2005-09-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:An oxyanion-hole selective serine protease inhibitor in complex with trypsin.
Bioorg.Med.Chem., 10, 2002
2ALV
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X-RAY STRUCTURAL ANALYSIS OF SARS CORONAVIRUS 3CL PROTEINASE IN COMPLEX WITH DESIGNED ANTI-VIRAL INHIBITORS
Descriptor:Replicase polyprotein 1ab, N-((3S,6R)-6-((S,E)-4-ETHOXYCARBONYL-1-((S)-2-OXOPYRROLIDIN-3-YL)BUT-3-EN-2-YLCARBAMOYL)-2,9-DIMETHYL-4-OXODEC-8-EN-3-YL)-5-METHYLISOXAZOLE-3-CARBOXAMIDE
Authors:Ghosh, A.K., Xi, K., Ratia, K., Santarsiero, B.D., Fu, W., Harcourt, B.H., Rota, P.A., Baker, S.C., Johnson, M.E., Mesecar, A.D.
Deposit date:2005-08-08
Release date:2006-08-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.
J.Med.Chem., 48, 2005
2MT9
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SOLUTION STRUCTURE OF HOLO_FLDB
Descriptor:Flavodoxin-2, FLAVIN MONONUCLEOTIDE
Authors:Jin, C., Fu, W., Ye, Q.
Deposit date:2014-08-15
Release date:2016-03-09
Last modified:2016-03-16
Method:SOLUTION NMR
Cite:Long-chain flavodoxin FldB from Escherichia coli
J.Biomol.Nmr, 60, 2014
2MTB
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SOLUTION STRUCTURE OF APO_FLDB
Descriptor:Flavodoxin-2
Authors:Jin, C., Fu, W., Ye, Q.
Deposit date:2014-08-15
Release date:2016-03-09
Method:SOLUTION NMR
Cite:Long-chain flavodoxin FldB from Escherichia coli
J.Biomol.Nmr, 60, 2014
5ZMM
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STRUCTURE OF THE TYPE IV PHOSPHOROTHIOATION-DEPENDENT RESTRICTION ENDONUCLEASE SCOMCRA
Descriptor:Uncharacterized protein McrA, ZINC ION, SULFATE ION
Authors:Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X.
Deposit date:2018-04-04
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
5ZMN
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SULFUR BINDING DOMAIN AND SRA DOMAIN OF SCOMCRA COMPLEXED WITH PHOSPHOROTHIOATED DNA
Descriptor:Uncharacterized protein McrA, DNA (5'-D(*CP*CP*CP*GP*(GS)P*CP*CP*GP*GP*G)-3'), SULFATE ION
Authors:Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X.
Deposit date:2018-04-04
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
5ZMO
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SULFUR BINDING DOMAIN OF SCOMCRA COMPLEXED WITH PHOSPHOROTHIOATED DNA
Descriptor:Uncharacterized protein McrA, DNA (5'-D(P*CP*CP*GP*(GS)P*CP*CP*GP*G)-3'), PHOSPHATE ION
Authors:Liu, G., Fu, W., Zhang, Z., He, Y., Yu, H., Zhao, Y., Deng, Z., Wu, G., He, X.
Deposit date:2018-04-04
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural basis for the recognition of sulfur in phosphorothioated DNA.
Nat Commun, 9, 2018
3WSQ
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STRUCTURE OF HER2 WITH AN FAB
Descriptor:Receptor tyrosine-protein kinase erbB-2, Antibody Light Chain, Antibody Heavy Chain
Authors:Fu, W.Y., Wang, Y.X., Zhou, L.J.
Deposit date:2014-03-20
Release date:2015-03-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies.
MAbs, 6, 2014
3WLW
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MOLECULAR ARCHITECTURE OF THE ERBB2 EXTRACELLULAR DOMAIN HOMODIMER
Descriptor:Receptor tyrosine-protein kinase erbB-2, Antibody H Chain, Antibody L Chain, ...
Authors:Hu, S., Lou, Z.Y., Guo, Y.J.
Deposit date:2013-11-15
Release date:2015-05-27
Method:X-RAY DIFFRACTION (3.088 Å)
Cite:Molecular architecture of the ErbB2 extracellular domain homodimer
Oncotarget, 6, 2015
1TX8
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BOVINE TRYPSIN COMPLEXED WITH AMSO
Descriptor:Trypsinogen, CALCIUM ION, 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE
Authors:Mesecar, A.D.
Deposit date:2004-07-02
Release date:2005-10-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa
Bioorg.Med.Chem.Lett., 14, 2004
2QIQ
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STRUCTURE-BASED DESIGN AND SYNTHESIS AND BIOLOGICAL EVALUATION OF PEPTIDOMIMETIC SARS-3CLPRO INHIBITORS
Descriptor:Replicase polyprotein 1ab, ETHYL (4R)-4-{[(2R,5S)-5-{[N-(TERT-BUTOXYCARBONYL)-L-SERYL]AMINO}-6-METHYL-2-(3-METHYLBUT-2-EN-1-YL)-4-OXOHEPTANOYL]AMINO}-5-[(3R)-2-OXOPYRROLIDIN-3-YL]PENTANOATE
Authors:Grum-Tokars, V.
Deposit date:2007-07-05
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
6A7Y
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SOLUTION STRUCTURE OF AN INTERMOLECULAR LEAPED V-SHAPE G-QUADRUPLEX
Descriptor:DNA (5'-D(*GP*GP*TP*TP*TP*TP*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3'), DNA (5'-D(*TP*GP*GP*GP*GP*A)-3')
Authors:Wan, C.J., Zhang, N.
Deposit date:2018-07-05
Release date:2018-12-12
Method:SOLUTION NMR
Cite:NMR solution structure of an asymmetric intermolecular leaped V-shape G-quadruplex: selective recognition of the d(G2NG3NG4) sequence motif by a short linear G-rich DNA probe.
Nucleic Acids Res., 2018