Author results

3L21
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THE CRYSTAL STRUCTURE OF A DIMERIC MUTANT OF DIHYDRODIPICOLINATE SYNTHASE (DAPA, RV2753C) FROM MYCOBACTERIUM TUBERCULOSIS - DHDPS-A204R
Descriptor:Dihydrodipicolinate synthase, SULFATE ION, GLYCEROL, ...
Authors:Evans, G.L., Schuldt, L., Jamerson, G.B., Devenish, S.R., Weiss, M.S., Gerrard, J.A.
Deposit date:2009-12-14
Release date:2010-12-15
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A dimeric mutant of DHDPS from Mycobacterium tuberculosis
To be Published
4GIU
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BIANTHRANILATE-LIKE ANALOGUE BOUND IN INNER SITE OF ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD).
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-08-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.667 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4GKM
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BIANTHRANILATE-LIKE ANALOGUE BOUND IN THE OUTER SITE OF ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-08-13
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6683 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4IJ1
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BIANTHRANILATE-LIKE ANALOGUE BOUND TO ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD) IN ABSENCE OF SUBSTRATES.
Descriptor:Anthranilate phosphoribosyltransferase, 2,2'-iminodibenzoic acid, GLYCEROL, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-12-20
Release date:2013-12-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4M0R
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TRIANTHRANILATE-LIKE ANALOGUE BOUND TO ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD).
Descriptor:Anthranilate phosphoribosyltransferase, 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, GLYCEROL, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-08-02
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem, 15, 2014
4ZOF
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LOBENZARIT-LIKE INHIBITOR BOUND IN THE ACTIVE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-06
Release date:2016-05-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
To be Published
4ZOJ
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METHYLSULFANYL-CONTAINING INHIBITOR BOUND IN THE ACTIVE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-06
Release date:2016-05-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
To be Published
4ZOK
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METHYLSULFONYL-CONTAINING INHIBITOR BOUND IN THE SUBSTRATE CAPTURE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-06
Release date:2016-05-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
To be Published
4ZTV
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NON-ANTHRANILATE-LIKE INHIBITOR (TAMU-A7) COMPLEXED WITH ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS IN ABSENCE OF PRPP
Descriptor:Anthranilate phosphoribosyltransferase, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione
Authors:Evans, G.L., Eom, J., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-15
Release date:2016-05-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis.
To be Published
5BNE
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BIANTHRANILATE-LIKE INHIBITOR WITH 6 ATOM "LINE" AND PHOSPHONATE "HOOK" FISHING FOR HYDROGEN BOND DONORS IN MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-[(5-phosphonopentyl)oxy]benzoic acid, IMIDAZOLE
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-26
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5BO2
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BIANTHRANILATE-LIKE INHIBITOR WITH 4-ATOM "LINE" AND PHOSPHONATE "HOOK" FISHING FOR HYDROGEN BOND DONORS IN MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-(3-phosphonopropoxy)benzoic acid, IMIDAZOLE
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-27
Release date:2016-06-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5BO3
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BIANTHRANILATE-LIKE INHIBITOR WITH 5 ATOM "LINE" AND PHOSPHONATE "HOOK" FISHING FOR HYDROGEN BOND DONORS IN MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, 2-[(2-carboxyphenyl)amino]-5-(4-phosphonobutoxy)benzoic acid, IMIDAZOLE
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-27
Release date:2016-06-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5BYT
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PRPP COMPLEXED WITH A SINGLE MG IN THE ACTIVE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-11
Release date:2016-07-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To be Published
5C1R
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STEREOISOMER OF PRPP BOUND IN THE ACTIVE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYL (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, ...
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-15
Release date:2016-07-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP.
To Be Published
5C2L
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MAGNESIUM SOAKED INTO THE ACTIVE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MAGNESIUM ION, IMIDAZOLE
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-16
Release date:2016-06-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP
To Be Published
5C7S
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PRPP COMPLEXED WITH TWO MN2+ IN THE ACTIVE SITE OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, MANGANESE (II) ION, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID
Authors:Evans, G.L., Baker, E.N., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-06-24
Release date:2016-06-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding and mimicking of the phosphate-rich substrate, PRPP
To Be Published
4N8Q
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ALTERNATIVE SUBSTRATES OF MYCOBACTERIUM TUBERCULOSIS ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE
Descriptor:Anthranilate phosphoribosyltransferase, 2-amino-4-fluorobenzoic acid
Authors:Castell, A., Cookson, T.V.M., Bulloch, E., Evans, G.L., Baker, E.N., Lott, J.S., Parker, E.J.
Deposit date:2013-10-17
Release date:2014-04-23
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4X58
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ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE VARIANT N138A FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PRPP AND MG
Descriptor:Anthranilate phosphoribosyltransferase, D-MALATE, GLYCEROL, ...
Authors:Cookson, T.V.M., Evans, G.L., Parker, E.J., Lott, J.S.
Deposit date:2014-12-04
Release date:2015-11-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X59
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE VARIANT P180A FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PRPP AND MG
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, GLYCEROL, ...
Authors:Cookson, T.V.M., Evans, G.L., Parker, E.J., Lott, J.S.
Deposit date:2014-12-04
Release date:2015-11-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
4X5E
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE VARIANT R194A FROM MYCOBACTERIUM TUBERCULOSIS WITH PYROPHOSPHATE, MG2+ AND ANTHRANILATE BOUND
Descriptor:Anthranilate phosphoribosyltransferase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Cookson, T.V.M., Evans, G.L., Parker, E.J., Lott, J.S.
Deposit date:2014-12-05
Release date:2015-11-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry, 54, 2015
5CWA
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STRUCTURE OF ANTHRANILATE SYNTHASE COMPONENT I (TRPE) FROM MYCOBACTERIUM TUBERCULOSIS WITH INHIBITOR BOUND
Descriptor:Anthranilate synthase component 1, SULFATE ION, GLYCEROL, ...
Authors:Johnston, J.M., Bashiri, G., Evans, G.L., Lott, J.S., Baker, E.N.
Deposit date:2015-07-28
Release date:2015-08-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
Acta Crystallogr.,Sect.D, 71, 2015
4YI7
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ANTHRANILATE BOUND AT ACTIVE SITE OF ANTHRANILATE PHOSPHORIBOSYL TRANSFERASE FROM ACINETOBACTER (ANPRT; TRPD)
Descriptor:Anthranilate phosphoribosyltransferase, 2-AMINOBENZOIC ACID
Authors:Evans, G.L., Newton, M.S., Norris, G.E., Patrick, W.M.
Deposit date:2015-02-28
Release date:2015-09-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:Substrate inhibition of protein in tryptophan biosynthesis pathway redirects flux to aromatic catabolism in Acinetobacter baylyi ADP1.
To Be Published
1XXX
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CRYSTAL STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE (DAPA, RV2753C) FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Dihydrodipicolinate synthase, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Kefala, G., Panjikar, S., Janowski, R., Weiss, M.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-11-09
Release date:2006-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Biochem.J., 411, 2008
3QQS
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (COMPLEX WITH INHIBITOR ACS172)
Descriptor:Anthranilate phosphoribosyltransferase, ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID, MAGNESIUM ION, ...
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-16
Release date:2012-08-22
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QR9
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (TRPD) FROM MYCOBACTERIUM TUBERCULOSIS (APO STRUCTURE)
Descriptor:Anthranilate phosphoribosyltransferase, GLYCEROL
Authors:Castell, A., Short, F.L., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-17
Release date:2011-06-15
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
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