Author results

1L8J
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CRYSTAL STRUCTURE OF THE ENDOTHELIAL PROTEIN C RECEPTOR AND BOUND PHOSPHOLIPID MOLECULE
Descriptor:Endothelial protein C receptor, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Oganesyan, V., Oganesyan, N., Terzyan, S., Dongfeng, Q., Dauter, Z., Esmon, N.L., Esmon, C.T.
Deposit date:2002-03-20
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the endothelial protein C receptor and a bound phospholipid.
J.Biol.Chem., 277, 2002
1LQV
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CRYSTAL STRUCTURE OF THE ENDOTHELIAL PROTEIN C RECEPTOR WITH PHOSPHOLIPID IN THE GROOVE IN COMPLEX WITH GLA DOMAIN OF PROTEIN C.
Descriptor:Endothelial protein C receptor, Vitamin-K dependent protein C, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V., Oganesyan, N., Terzyan, S., Dongfeng, Q., Dauter, Z., Esmon, N.L., Esmon, C.T.
Deposit date:2002-05-13
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of the endothelial protein C receptor and a bound phospholipid.
J.Biol.Chem., 277, 2002
1A0H
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THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN
Descriptor:MEIZOTHROMBIN, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, N-ACETYL-D-GLUCOSAMINE
Authors:Martin, P.D., Malkowski, M.G., Box, J., Esmon, C.T., Edwards, B.F.P.
Deposit date:1997-11-30
Release date:1998-06-17
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.
Structure, 5, 1997
1JMO
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CRYSTAL STRUCTURE OF THE HEPARIN COFACTOR II-S195A THROMBIN COMPLEX
Descriptor:Thrombin, light chain, heavy chain, ...
Authors:Baglin, T.P., Carrell, R.W., Esmon, C.T., Huntington, J.A.
Deposit date:2001-07-19
Release date:2002-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JOU
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CRYSTAL STRUCTURE OF NATIVE S195A THROMBIN WITH AN UNOCCUPIED ACTIVE SITE
Descriptor:Thrombin, light chain, heavy chain, ...
Authors:Huntington, J.A., Esmon, C.T.
Deposit date:2001-07-31
Release date:2001-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
Structure, 11, 2003
1TB6
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2.5A CRYSTAL STRUCTURE OF THE ANTITHROMBIN-THROMBIN-HEPARIN TERNARY COMPLEX
Descriptor:thrombin, Antithrombin-III, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Li, W., Johnson, D.J., Esmon, C.T., Huntington, J.A.
Deposit date:2004-05-19
Release date:2004-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
Nat.Struct.Mol.Biol., 11, 2004
3JTC
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IMPORTANCE OF MG2+ IN THE CA2+-DEPENDENT FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID DOMAINS OF VITAMIN K-DEPENDENT CLOTTING AND ANTICLOTTING PROTEINS
Descriptor:Endothelial protein C receptor, Vitamin K-dependent protein C, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bajaj, S.P., Vadivel, K., Agah, S., Cascio, D., Krishnaswamy, S., Esmon, C., Padmanabhan, K.
Deposit date:2009-09-11
Release date:2011-04-06
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.
J.Mol.Biol., 425, 2013
1BTH
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STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
Descriptor:THROMBIN, BOVINE PANCREATIC TRYPSIN INHIBITOR
Authors:Van De Locht, A., Bode, W., Stubbs, M.T.
Deposit date:1996-12-03
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin.
EMBO J., 16, 1997
1ID5
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CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEX WITH PROTEASE INHIBITOR ECOTIN
Descriptor:THROMBIN, ECOTIN, CALCIUM ION, ...
Authors:Wang, S.X., Fletterick, R.J.
Deposit date:2001-04-03
Release date:2001-09-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions.
Biochemistry, 40, 2001
1JMJ
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CRYSTAL STRUCTURE OF NATIVE HEPARIN COFACTOR II
Descriptor:HEPARIN COFACTOR II, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Baglin, T.P., Carrell, R.W., Church, F.C., Huntington, J.A.
Deposit date:2001-07-18
Release date:2002-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
3B9F
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1.6 A STRUCTURE OF THE PCI-THROMBIN-HEPARIN COMPLEX
Descriptor:Prothrombin, Plasma serine protease inhibitor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Li, W., Adams, T.E., Huntington, J.A.
Deposit date:2007-11-05
Release date:2008-04-22
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3TH3
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MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+
Descriptor:Coagulation factor VII light chain, Coagulation factor VII heavy chain, Tissue factor, ...
Authors:Vadivel, K., Agah, S., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published
3TH4
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MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THE GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMIN K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+
Descriptor:Coagulation factor VII light chain, Coagulation factor VII heavy chain, Tissue factor, ...
Authors:Vadivel, K., Agah, S., Cascio, D., Padmanabhan, K., Bajaj, S.P.
Deposit date:2011-08-18
Release date:2012-08-22
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+
To be Published
3E6P
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CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1
Descriptor:Prothrombin, SULFATE ION, D-PHENYLALANYL-N-[(1S)-4-{[(Z)-AMINO(IMINO)METHYL]AMINO}-1-(CHLOROACETYL)BUTYL]-L-PROLINAMIDE, ...
Authors:Papaconstantinou, M.E., Gandhi, P., Chen, Z., Bah, A., Di Cera, E.
Deposit date:2008-08-15
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Na(+) binding to meizothrombin desF1.
Cell.Mol.Life Sci., 65, 2008