1A0H

THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN

Summary for 1A0H

Related PRD IDPRD_000020
DescriptorMEIZOTHROMBIN, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, N-ACETYL-D-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsserine protease, coagulation, thrombin, prothrombin, meizothrombin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceBos taurus (cattle)
Cellular locationSecreted, extracellular space P00735 P00735
Total number of polymer chains4
Total molecular weight97074.32
Authors
Martin, P.D.,Malkowski, M.G.,Box, J.,Esmon, C.T.,Edwards, B.F.P. (deposition date: 1997-11-30, release date: 1998-06-17, Last modification date: 2013-02-27)
Primary citation
Martin, P.D.,Malkowski, M.G.,Box, J.,Esmon, C.T.,Edwards, B.F.
New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.
Structure, 5:1681-1693, 1997
PubMed: 9438869 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(97)00314-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers428.0%16.4%6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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