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5M93
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BU of 5m93 by Molmil
Crystal structure of SdeA-modified ubiquitin.
Descriptor: Polyubiquitin-B, SULFATE ION, alpha-D-ribofuranose
Authors:Kalayil, S, Bhogaraju, S, Dikic, I.
Deposit date:2016-10-31
Release date:2016-12-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.
Cell, 167, 2016
8Q7K
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BU of 8q7k by Molmil
IRGQ LIR2 peptide in complex with LC3B
Descriptor: 1,2-ETHANEDIOL, Immunity-related GTPase family Q protein, Microtubule-associated proteins 1A/1B light chain 3B
Authors:Misra, M, Bailey, H.J, Pomirska, J, Dikic, I.
Deposit date:2023-08-16
Release date:2024-08-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Tumor immune evasion through IRGQ-directed autophagy
To Be Published
2AK5
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BU of 2ak5 by Molmil
beta PIX-SH3 complexed with a Cbl-b peptide
Descriptor: 8-residue peptide from a signal transduction protein CBL-B, Rho guanine nucleotide exchange factor 7
Authors:Jozic, D, Cardenes, N, Deribe, Y.L, Moncalian, G, Hoeller, D, Groemping, Y, Dikic, I, Rittinger, K, Bravo, J.
Deposit date:2005-08-03
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cbl promotes clustering of endocytic adaptor proteins.
Nat.Struct.Mol.Biol., 12, 2005
2KHW
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BU of 2khw by Molmil
Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex
Descriptor: Immunoglobulin G-binding protein G, DNA polymerase iota, Ubiquitin
Authors:Bomar, M.G, D'Souza, S, Bienko, M, Dikic, I, Walker, G.
Deposit date:2009-04-13
Release date:2010-02-23
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex
To be Published
6N6R
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BU of 6n6r by Molmil
Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins
Descriptor: TNFAIP3-interacting protein 1, Ubiquitin
Authors:Rahighi, S, Dikic, I, Wakatsuki, S.
Deposit date:2018-11-27
Release date:2019-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
6N6S
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BU of 6n6s by Molmil
Crystal structure of ABIN-1 UBAN
Descriptor: TNFAIP3-interacting protein 1
Authors:Rahighi, S, Dikic, I, Wakatsuki, S.
Deposit date:2018-11-27
Release date:2019-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
6N5M
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BU of 6n5m by Molmil
Crystal structure of ABIN-1 UBAN in complex with one M1-linked di-ubiquitin
Descriptor: Polyubiquitin-C, TNFAIP3-interacting protein 1
Authors:Rahighi, S, Dikic, I, Wakatsuki, S.
Deposit date:2018-11-22
Release date:2019-07-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains.
J.Mol.Biol., 431, 2019
6XX0
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BU of 6xx0 by Molmil
Crystal structure of NEMO in complex with Ubv-LIN
Descriptor: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b, ...
Authors:Akutsu, M, Skenderovic, A, Garcia-Pardo, J, Maculins, T, Dikic, I.
Deposit date:2020-01-26
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Cell Chem Biol, 27, 2020
3F89
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BU of 3f89 by Molmil
NEMO CoZi domain
Descriptor: NF-kappa-B essential modulator
Authors:Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I.
Deposit date:2008-11-11
Release date:2009-03-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
5JW7
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BU of 5jw7 by Molmil
Crystal structure of SopA-Trim56 complex
Descriptor: E3 ubiquitin-protein ligase SopA, E3 ubiquitin-protein ligase TRIM56, ZINC ION
Authors:Bhogaraju, S, Dikic, I.
Deposit date:2016-05-11
Release date:2017-02-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.849 Å)
Cite:Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.
Nat Commun, 8, 2017
4EMO
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BU of 4emo by Molmil
Crystal structure of the PH domain of SHARPIN
Descriptor: Sharpin
Authors:Stieglitz, B, Haire, L.F, Dikic, I, Rittinger, K.
Deposit date:2012-04-12
Release date:2012-05-02
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold.
J.Biol.Chem., 287, 2012
2R2Y
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BU of 2r2y by Molmil
Crystal structure of the proteasomal Rpn13 PRU-domain
Descriptor: Protein ADRM1
Authors:Groll, M, Walters, K, Dikic, I, Finley, D.
Deposit date:2007-08-28
Release date:2008-05-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Nature, 453, 2008
4ZDV
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BU of 4zdv by Molmil
Crystal structure of LC3 in complex with FAM134B LIR
Descriptor: Microtubule-associated proteins 1A/1B light chain 3A
Authors:Khaminets, A, Grumati, P, Dikic, I, Akutsu, M.
Deposit date:2015-04-19
Release date:2015-06-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Regulation of endoplasmic reticulum turnover by selective autophagy.
Nature, 522, 2015
6YVA
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BU of 6yva by Molmil
PLpro-C111S with mISG15
Descriptor: Replicase polyprotein 1a, Ubiquitin-like protein ISG15, ZINC ION
Authors:Shin, D, Dikic, I.
Deposit date:2020-04-28
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Nature, 587, 2020
8Q6Q
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BU of 8q6q by Molmil
Structure of human immunity related GTPase Q in complex with GABARAPL2.
Descriptor: CITRIC ACID, Gamma-aminobutyric acid receptor-associated protein-like 2, Immunity-related GTPase family Q protein
Authors:Bailey, H.J, Misra, M, Pomirska, J, Dikic, I.
Deposit date:2023-08-14
Release date:2024-08-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human immunity related GTPase Q in complex with GABARAPL2.
To Be Published
3X0W
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BU of 3x0w by Molmil
Crystal structure of PLEKHM1 LIR-fused human LC3B_2-119
Descriptor: Microtubule-associated proteins 1A/1B light chain 3B
Authors:Suzuki, H, McEwan, D.G, Popovic, D, Gubas, A, Terawaki, S, Stadel, D, Coxon, F, Stegmann, D.M, Bhogaraju, S, Maddi, K, Kirchhoff, A, Gatti, E, Helfrich, M.H, Behrends, C, Pierre, P, Dikic, I, Wakatsuki, S.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
Mol.Cell, 57, 2015
6G0C
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BU of 6g0c by Molmil
Crystal structure of SdeA catalytic core
Descriptor: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Ubiquitinating/deubiquitinating enzyme SdeA
Authors:Kalayil, S, Bhogaraju, S, Basquin, J, Dikic, I.
Deposit date:2018-03-17
Release date:2018-05-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination.
Nature, 557, 2018
4P09
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BU of 4p09 by Molmil
Crystal structure of HOIP PUB domain
Descriptor: E3 ubiquitin-protein ligase RNF31
Authors:Akutsu, M, Schaeffer, V, Olma, M.H, Gomes, L.C, Kawasaki, M, Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4P0A
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BU of 4p0a by Molmil
Crystal structure of HOIP PUB domain in complex with p97 PIM
Descriptor: E3 ubiquitin-protein ligase RNF31, Transitional endoplasmic reticulum ATPase
Authors:Akutsu, M, Schaeffer, V, Olma, M.H, Gomes, L.C, Kawasaki, M, Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3001 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4P0B
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BU of 4p0b by Molmil
Crystal structure of HOIP PUB domain in complex with OTULIN PIM
Descriptor: E3 ubiquitin-protein ligase RNF31, Ubiquitin thioesterase otulin
Authors:Akutsu, M, Schaeffer, V, Olma, M.H, Gomes, L.C, Kawasaki, M, Dikic, I.
Deposit date:2014-02-20
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7005 Å)
Cite:Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54, 2014
4MRT
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BU of 4mrt by Molmil
Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein
Descriptor: 4'-phosphopantetheinyl transferase sfp, COENZYME A, GLYCEROL, ...
Authors:Tufar, P, Rahighi, S, Kraas, F.I, Kirchner, D.K, Loehr, F, Henrich, E, Koepke, J, Dikic, I, Guentert, P, Marahiel, M.A, Doetsch, V.
Deposit date:2013-09-17
Release date:2014-04-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
2L8J
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BU of 2l8j by Molmil
GABARAPL-1 NBR1-LIR complex structure
Descriptor: Gamma-aminobutyric acid receptor-associated protein-like 1, NBR1-LIR peptide
Authors:Rogov, V.V, Rozenknop, A, Rogova, N.Y, Loehr, F, Guentert, P, Dikic, I, Doetsch, V.
Deposit date:2011-01-17
Release date:2011-05-11
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1.
J.Mol.Biol., 410, 2011
2MD9
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BU of 2md9 by Molmil
Solution Structure of an Active Site Mutant Pepitdyl Carrier Protein
Descriptor: Tyrocidine synthase 3
Authors:Tufar, P, Rahighi, S, Kraas, F.I, Kirchner, D.K, Loehr, F, Henrich, E, Koepke, J, Dikic, I, Guentert, P, Marahiel, M.A, Doetsch, V.
Deposit date:2013-09-06
Release date:2014-04-23
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification.
Chem.Biol., 21, 2014
2O2O
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BU of 2o2o by Molmil
Solution structure of domain B from human CIN85 PROTEIN
Descriptor: SH3-domain kinase-binding protein 1
Authors:Ababou, A, Pfuhl, M, Dikic, I, Ladbury, J.E.
Deposit date:2006-11-30
Release date:2007-11-13
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Investigation of Domain B from Human Cin85 Protein: Structure, Dynamics and Proline-Rich Motif Binding
To be Published
6YK8
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BU of 6yk8 by Molmil
OTU-like deubiquitinase from Legionella -Lpg2529
Descriptor: PLATINUM (II) ION, Uncharacterized protein
Authors:Shin, D, Dikic, I.
Deposit date:2020-04-05
Release date:2021-02-10
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection.
Elife, 9, 2020

 

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