6YVA

PLpro-C111S with mISG15

Summary for 6YVA

• Entry DOI: 10.2210/pdb6yva/pdb
• Descriptor: Replicase polyprotein 1a, Ubiquitin-like protein ISG15, ZINC ION, ... (4 entities in total)
• Functional Keywords: deubiquitinase, papain-like-protease, sars-cov-2, isg15, complex, cell invasion
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 2
• Total formula weight: 53640.48

Authors

Shin, D.,Dikic, I. (deposition date: 2020-04-28, release date: 2020-05-13, Last modification date: 2024-01-24)

• Primary citation: Shin, D.,Mukherjee, R.,Grewe, D.,Bojkova, D.,Baek, K.,Bhattacharya, A.,Schulz, L.,Widera, M.,Mehdipour, A.R.,Tascher, G.,Geurink, P.P.,Wilhelm, A.,van der Heden van Noort, G.J.,Ovaa, H.,Muller, S.,Knobeloch, K.P.,Rajalingam, K.,Schulman, B.A.,Cinatl, J.,Hummer, G.,Ciesek, S.,Dikic, I.; Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.; Nature, 587:657-662, 2020; PubMed: 32726803; DOI: 10.1038/s41586-020-2601-5

Experimental method

X-RAY DIFFRACTION (3.18 Å)