6YVA
PLpro-C111S with mISG15
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0002682 | biological_process | regulation of immune system process |
| C | 0003735 | molecular_function | structural constituent of ribosome |
| C | 0005178 | molecular_function | integrin binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0007229 | biological_process | integrin-mediated signaling pathway |
| C | 0009615 | biological_process | response to virus |
| C | 0009617 | biological_process | response to bacterium |
| C | 0019941 | biological_process | modification-dependent protein catabolic process |
| C | 0022626 | cellular_component | cytosolic ribosome |
| C | 0030501 | biological_process | positive regulation of bone mineralization |
| C | 0031386 | molecular_function | protein tag activity |
| C | 0031397 | biological_process | negative regulation of protein ubiquitination |
| C | 0032020 | biological_process | ISG15-protein conjugation |
| C | 0032461 | biological_process | positive regulation of protein oligomerization |
| C | 0032649 | biological_process | regulation of type II interferon production |
| C | 0032728 | biological_process | positive regulation of interferon-beta production |
| C | 0032729 | biological_process | positive regulation of type II interferon production |
| C | 0032733 | biological_process | positive regulation of interleukin-10 production |
| C | 0034340 | biological_process | response to type I interferon |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0045071 | biological_process | negative regulation of viral genome replication |
| C | 0045087 | biological_process | innate immune response |
| C | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| C | 0051240 | biological_process | positive regulation of multicellular organismal process |
| C | 0051607 | biological_process | defense response to virus |
| C | 0060339 | biological_process | negative regulation of type I interferon-mediated signaling pathway |
| C | 0070585 | biological_process | protein localization to mitochondrion |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 133 |
| Details | Domain: {"description":"Ubiquitin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32726803","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For PL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 74 |
| Details | Domain: {"description":"Ubiquitin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"Involved in the ligation of specific target proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LRLRGG","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"18606809","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
