4EMO

Crystal structure of the PH domain of SHARPIN

Summary for 4EMO

Entry DOI	10.2210/pdb4emo/pdb
Descriptor	Sharpin (2 entities in total)
Functional Keywords	pleckstrin homology (ph) domain, lubac, sipl1, linear ubiquitin, hoil-1l, hoip, protein binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol: Q9H0F6
Total number of polymer chains	4
Total formula weight	53422.10
Authors	Stieglitz, B.,Haire, L.F.,Dikic, I.,Rittinger, K. (deposition date: 2012-04-12, release date: 2012-05-02, Last modification date: 2012-07-25)
Primary citation	Stieglitz, B.,Haire, L.F.,Dikic, I.,Rittinger, K. Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold. J.Biol.Chem., 287:20823-20829, 2012 Cited by PubMed: 22549881 DOI: 10.1074/jbc.M112.359547 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation