4EMO
Crystal structure of the PH domain of SHARPIN
Summary for 4EMO
Entry DOI | 10.2210/pdb4emo/pdb |
Descriptor | Sharpin (2 entities in total) |
Functional Keywords | pleckstrin homology (ph) domain, lubac, sipl1, linear ubiquitin, hoil-1l, hoip, protein binding |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol: Q9H0F6 |
Total number of polymer chains | 4 |
Total formula weight | 53422.10 |
Authors | Stieglitz, B.,Haire, L.F.,Dikic, I.,Rittinger, K. (deposition date: 2012-04-12, release date: 2012-05-02, Last modification date: 2012-07-25) |
Primary citation | Stieglitz, B.,Haire, L.F.,Dikic, I.,Rittinger, K. Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold. J.Biol.Chem., 287:20823-20829, 2012 Cited by PubMed: 22549881DOI: 10.1074/jbc.M112.359547 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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