Crystal structure of HOIP PUB domain in complex with p97 PIM

Summary for 4P0A

DescriptorE3 ubiquitin-protein ligase RNF31, Transitional endoplasmic reticulum ATPase (3 entities in total)
Functional Keywordshoip, pub domain, p97, pim, ligase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  Q96EP0
Cytoplasm, cytosol  P55072
Total number of polymer chains4
Total molecular weight43854.88
Akutsu, M.,Schaeffer, V.,Olma, M.H.,Gomes, L.C.,Kawasaki, M.,Dikic, I. (deposition date: 2014-02-20, release date: 2014-05-07, Last modification date: 2017-11-22)
Primary citation
Schaeffer, V.,Akutsu, M.,Olma, M.H.,Gomes, L.C.,Kawasaki, M.,Dikic, I.
Binding of OTULIN to the PUB domain of HOIP controls NF-kappa B signaling.
Mol.Cell, 54:349-361, 2014
PubMed: 24726327 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2014.03.016
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25140 3.9% 5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-18