Author results

1EAZ
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CRYSTAL STRUCTURE OF THE PHOSPHOINOSITOL (3,4)-BISPHOSPHATE BINDING PH DOMAIN OF TAPP1 FROM HUMAN.
Descriptor:TANDEM PH DOMAIN CONTAINING PROTEIN-1, CITRIC ACID
Authors:Thomas, C.C., Dowler, S., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2001-07-17
Release date:2002-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of the Phosphatidylinositol 3,4-Bisphosphate-Binding Pleckstrin Homology (Ph) Domain of Tandem Ph-Domain-Containing Protein 1 (Tapp1): Molecular Basis of Lipid Specificity
Biochem.J., 358, 2001
1UNP
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CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PKB ALPHA
Descriptor:RAC-ALPHA SERINE/THREONINE KINASE
Authors:Milburn, C.C., Deak, M., Kelly, S.M., Price, N.C., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2003-09-12
Release date:2004-09-16
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
1UNQ
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS(1,3,4,5)-TETRAKISPHOPHATE
Descriptor:RAC-ALPHA SERINE/THREONINE KINASE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Milburn, C.C., Deak, M., Kelly, S.M., Price, N.C., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2003-09-12
Release date:2004-09-16
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
1UNR
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CRYSTAL STRUCTURE OF THE PH DOMAIN OF PKB ALPHA IN COMPLEX WITH A SULFATE MOLECULE
Descriptor:RAC-ALPHA SERINE/THREONINE KINASE, SULFATE ION
Authors:Milburn, C.C., Deak, M., Kelly, S.M., Price, N.C., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2003-09-15
Release date:2004-09-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
1W1D
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CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1,3,4,5)-TETRAKISPHOSPHATE
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, GOLD ION, ...
Authors:Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1UU3
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-15
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU7
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU8
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU9
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UVR
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Garrido-Franco, M., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-01-22
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1H10
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HIGH RESOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS(1,3,4,5)-TETRAKISPHOPHATE
Descriptor:RAC-ALPHA SERINE/THREONINE KINASE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Thomas, C.C., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2002-07-01
Release date:2003-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate
Curr.Biol., 12, 2002
1H1W
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Biondi, R.M., Komander, D., Thomas, C.C., Lizcano, J.M., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2002-07-23
Release date:2003-07-17
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:High Resolution Crystal Structure of the Human Pdk1 Catalytic Domain Defines the Regulatory Phosphopeptide Docking Site
Embo J., 21, 2003
1UPK
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CRYSTAL STRUCTURE OF MO25 IN COMPLEX WITH A C-TERMINAL PEPTIDE OF STRAD
Descriptor:MO25 PROTEIN, STE-20 RELATED ADAPTOR, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Milburn, C.C., Boudeau, J., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-10-07
Release date:2004-01-22
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
1UPL
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CRYSTAL STRUCTURE OF MO25 ALPHA
Descriptor:MO25 PROTEIN
Authors:Milburn, C.C., Boudeau, J., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-10-07
Release date:2004-01-22
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
1UPQ
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CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY (PH) DOMAIN OF PEPP1
Descriptor:PEPP1, SULFATE ION
Authors:Milburn, C.C., Komander, D., Deak, M., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2003-10-09
Release date:2004-10-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of the Pleckstrin Homology Domain of Pepp1
To be Published
1UPR
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CRYSTAL STRUCTURE OF THE PEPP1 PLECKSTRIN HOMOLOGY DOMAIN IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
Descriptor:PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 4, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
Authors:Milburn, C.C., Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-10-10
Release date:2004-10-20
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of the Pleckstrin Homology Domain of Pepp1
To be Published
1W1G
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CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4-PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE
Authors:Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1W1H
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CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION
Authors:Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1WCH
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CRYSTAL STRUCTURE OF PTPL1 HUMAN TYROSINE PHOSPHATASE MUTATED IN COLORECTAL CANCER - EVIDENCE FOR A SECOND PHOSPHOTYROSINE SUBSTRATE RECOGNITION POCKET
Descriptor:PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13, PHOSPHATE ION
Authors:Villa, F., Deak, M., Bloomberg, G.B., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-11-16
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket
J.Biol.Chem., 280, 2005
2BIY
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STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Deak, M., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2005-01-26
Release date:2005-02-23
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
J. Biol. Chem., 280, 2005
2V3S
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STRUCTURAL INSIGHTS INTO THE RECOGNITION OF SUBSTRATES AND ACTIVATORS BY THE OSR1 KINASE
Descriptor:SERINE/THREONINE-PROTEIN KINASE OSR1, SERINE/THREONINE-PROTEIN KINASE WNK4, ACETATE ION
Authors:Villa, F., Goebel, J., Rafiqi, F.H., Deak, M., Thastrup, J., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2007-06-21
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights Into the Recognition of Substrates and Activators by the Osr1 Kinase
Embo Rep., 8, 2007
2VWI
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STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET
Descriptor:SERINE/THREONINE-PROTEIN KINASE OSR1, GOLD ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Villa, F., Deak, M., Alessi, D.R., vanAalten, D.M.F.
Deposit date:2008-06-25
Release date:2008-07-08
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the Osr1 Kinase, a Hypertension Drug Target.
Proteins, 73, 2008
4QLB
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STRUCTURAL BASIS FOR THE RECRUITMENT OF GLYCOGEN SYNTHASE BY GLYCOGENIN
Descriptor:Probable glycogen [starch] synthase, Protein GYG-1, isoform b, ...
Authors:Zeqiraj, E., Judd, A., Sicheri, F.
Deposit date:2014-06-11
Release date:2014-07-09
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc.Natl.Acad.Sci.USA, 111, 2014
2VKI
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STRUCTURE OF THE PDK1 PH DOMAIN K465E MUTANT
Descriptor:3-PHOPSHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION
Authors:Komander, D., Bayascas, J.R., Deak, M., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2007-12-19
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation of the Pdk1 Ph Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance.
Mol.Cell.Biol., 28, 2008
2WTK
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STRUCTURE OF THE HETEROTRIMERIC LKB1-STRADALPHA-MO25ALPHA COMPLEX
Descriptor:CALCIUM-BINDING PROTEIN 39, STE20-RELATED KINASE ADAPTER PROTEIN ALPHA, SERINE/THREONINE-PROTEIN KINASE 11, ...
Authors:Zeqiraj, E., van Aalten, D.M.F.
Deposit date:2009-09-16
Release date:2009-12-15
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation.
Science, 326, 2009
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