1UU7

Structure of human PDK1 kinase domain in complex with BIM-2

Summary for 1UU7

Related1H1W 1OKY 1OKZ 1UU3 1UU8 1UU9 1UVR
Descriptor3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, ... (5 entities in total)
Functional Keywordsprotein kinase, pkb, pdk1, inhibitor, ly333531, bisindolyl maleimide, bim-1, diabetes, cancer, transferase, serine/threonine-protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight36689.84
Authors
Komander, D.,Kular, G.S.,Schuttelkopf, A.W.,Deak, M.,Prakash, K.R.,Bain, J.,Elliot, M.,Garrido-Franco, M.,Kozikowski, A.P.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-12-16, release date: 2004-03-04, Last modification date: 2019-04-24)
Primary citation
Komander, D.,Kular, G.S.,Schuttelkopf, A.W.,Deak, M.,Prakash, K.R.,Bain, J.,Elliot, M.,Garrido-Franco, M.,Kozikowski, A.P.,Alessi, D.R.,Van Aalten, D.M.F.
Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12:215-, 2004
PubMed: 14962382 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2004.01.005
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.2828 0.4% 5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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