1UU7

Structure of human PDK1 kinase domain in complex with BIM-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1365

Chain	Residue
A	LYS76
A	ARG131
A	THR148
A	PHE149
A	GLN150

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A1366

Chain	Residue
A	HOH2115
A	HOH2194
A	TYR146
A	SER160
A	GLN220
A	GOL1362

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1367

Chain	Residue
A	ARG106
A	HIS351
A	GOL1362

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A1368

Chain	Residue
A	GLY91
A	SER92
A	PHE93
A	SER94

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE BI2 A1364

Chain	Residue
A	LEU88
A	GLY89
A	ALA109
A	LYS111
A	VAL143
A	LEU159
A	SER160
A	TYR161
A	ALA162
A	GLU166
A	GLU209
A	ASN210
A	LEU212
A	THR222
A	HOH2106
A	HOH2192

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1360

Chain	Residue
A	PRO79
A	LYS154
A	TYR156
A	GLU328
A	GLU331
A	GLY332
A	HOH2191

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1361

Chain	Residue
A	PHE82
A	LYS83
A	PHE84
A	GLU194
A	GLY334
A	LYS337
A	HOH2009

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1362

Chain	Residue
A	ARG106
A	GLU107
A	SER160
A	TYR161
A	SO41366
A	SO41367
A	HOH2078

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A1363

Chain	Residue
A	ALA103
A	THR104
A	SER105
A	HIS139
A	SER191
A	TRP347
A	ASN349
A	LEU350
A	HIS351

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSFSTVVlArelatsre..........YAIK

Chain	Residue	Details
A	LEU88-LYS111

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNILL

Chain	Residue	Details
A	ILE201-LEU213

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP205

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:12169624, ECO:0000269|PubMed:15741170, ECO:0000269|PubMed:22999883

Chain	Residue	Details
A	LYS111
A	SER160
A	GLU166
A	ASP223
A	SER92

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:22999883

Chain	Residue	Details
A	GLU209

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:10455013, ECO:0000269|PubMed:11481331, ECO:0000269|PubMed:15772071, ECO:0000269|PubMed:16780920, ECO:0000269|Ref.8

Chain	Residue	Details
A	SEP241

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z2A0

Chain	Residue	Details
A	LYS304

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MELK => ECO:0000269|PubMed:22544756

Chain	Residue	Details
A	THR354

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