1UU3

Structure of human PDK1 kinase domain in complex with LY333531

Summary for 1UU3

Related1H1W 1OKY 1OKZ 1UU7 1UU8 1UU9 1UVR
Descriptor3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywordsprotein kinase, pkb, pdk1, inhibitor, ly333531, diabetes, cancer, transferase, serine/threonine-protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight37376.43
Authors
Komander, D.,Kular, G.S.,Schuttelkopf, A.W.,Deak, M.,Prakash, K.R.,Bain, J.,Elliot, M.,Garrido-Franco, M.,Kozikowski, A.P.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-12-15, release date: 2004-03-04, Last modification date: 2019-04-24)
Primary citation
Komander, D.,Kular, G.S.,Schuttelkopf, A.W.,Deak, M.,Prakash, K.R.,Bain, J.,Elliot, M.,Garrido-Franco, M.,Kozikowski, A.P.,Alessi, D.R.,Van Aalten, D.M.F.
Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12:215-, 2004
PubMed: 14962382 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2004.01.005
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2162 0.4% 0.4% 4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution