3SMC
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3SMB
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2QFJ
| Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE | Descriptor: | DNA (5'-D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DTP*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3'), FBP-interacting repressor | Authors: | Crichlow, G.V, Yang, Y, Fan, C, Lolis, E, Braddock, D. | Deposit date: | 2007-06-27 | Release date: | 2008-03-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition EMBO J., 27, 2007
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3CE4
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3DJI
| Crystal Structure of Macrophage Migration Inhibitory Factor Bound to an Acetaminophen Dimer Derived from NAPQI | Descriptor: | CHLORIDE ION, Macrophage migration inhibitory factor, N,N'-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacetamide | Authors: | Crichlow, G.V, Lolis, E. | Deposit date: | 2008-06-23 | Release date: | 2008-12-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry, 48, 2009
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3DJH
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1GA0
| STRUCTURE OF THE E. CLOACAE GC1 BETA-LACTAMASE WITH A CEPHALOSPORIN SULFONE INHIBITOR | Descriptor: | 3-(4-CARBAMOYL-1-CARBOXY-2-METHYLSULFONYL-BUTA-1,3-DIENYLAMINO)-INDOLIZINE-2-CARBOXYLIC ACID, BETA-LACTAMASE, GLYCEROL, ... | Authors: | Crichlow, G.V, Nukaga, M, Buynak, J.D, Knox, J.R. | Deposit date: | 2000-11-28 | Release date: | 2001-06-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone. Biochemistry, 40, 2001
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1GCE
| STRUCTURE OF THE BETA-LACTAMASE OF ENTEROBACTER CLOACAE GC1 | Descriptor: | BETA-LACTAMASE | Authors: | Crichlow, G.V, Kuzin, A.P, Nukaga, M, Sawai, T, Knox, J.R. | Deposit date: | 1999-05-17 | Release date: | 1999-08-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the extended-spectrum class C beta-lactamase of Enterobacter cloacae GC1, a natural mutant with a tandem tripeptide insertion. Biochemistry, 38, 1999
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2OOW
| MIF Bound to a Fluorinated OXIM Derivative | Descriptor: | 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ... | Authors: | Crichlow, G.V, Al-Abed, Y, Lolis, E. | Deposit date: | 2007-01-26 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
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2OOZ
| Macrophage Migration Inhibitory Factor (MIF) Complexed with OXIM6 (an OXIM Derivative Not Containing a Ring in its R-group) | Descriptor: | 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ... | Authors: | Crichlow, G.V, Al-Abed, Y, Lolis, E. | Deposit date: | 2007-01-26 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
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2OOH
| Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11 | Descriptor: | 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, Macrophage migration inhibitory factor, ... | Authors: | Crichlow, G.V, Al-Abed, Y, Lolis, E. | Deposit date: | 2007-01-25 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
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4K9G
| 1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound | Descriptor: | (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, CHLORIDE ION, ... | Authors: | Crichlow, G.V, Al-Abed, Y, Lolis, E.J. | Deposit date: | 2013-04-19 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL., 45, 2014
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5KW1
| Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue | Descriptor: | CHLORIDE ION, DNA/RNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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5KWQ
| Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60 | Descriptor: | Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Yang, Y, Zhou, H, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-18 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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5KW6
| Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base | Descriptor: | DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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3IJJ
| Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) | Descriptor: | (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... | Authors: | Crichlow, G.V, Cho, Y, Lolis, E.J. | Deposit date: | 2009-08-04 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
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3IJG
| Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013 | Descriptor: | (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Crichlow, G.V, Cho, Y, Lolis, E.J. | Deposit date: | 2009-08-04 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
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8TT9
| X-ray structure of Macrophage Migration Inhibitory Factor (MIF) Covalently Bound to 4-hydroxyphenylpyruvate (HPP) | Descriptor: | 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor | Authors: | Schroder, G.C, Meilleur, F, Nix, J.C, Crichlow, G.V, Lolis, E.J. | Deposit date: | 2023-08-13 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | X-ray structure of Macrophage Migration Inhibitory Factor (MIF) Covalently Bound to 4-hydroxyphenylpyruvate (HPP) To Be Published
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5KVY
| CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG | Descriptor: | CHLORIDE ION, DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Hsiao, H.-H, Crichlow, G.V, Albright, R.A, Murphy, J.W, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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1HZO
| STRUCTURE OF CLASS A CEPHALOSPORINASE FROM PROTEUS VULGARIS K1 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-LACTAMASE | Authors: | Nukaga, M, Crichlow, G.V, Kuzin, A.P, Mayama, K, Knox, J.R. | Deposit date: | 2001-01-25 | Release date: | 2002-04-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of an extended-spectrum class A beta-lactamase from Proteus vulgaris K1. J.Mol.Biol., 317, 2002
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3B9S
| Macrophage Migration Inhibitory Factor (MIF) complexed with Inhibitor, 4-IPP. | Descriptor: | 4-phenylpyrimidine, GLYCEROL, Macrophage Migration Inhibitory Factor, ... | Authors: | Zierow, S, Crichlow, G, Lolis, E. | Deposit date: | 2007-11-06 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res., 68, 2008
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1MSB
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1YTT
| YB SUBSTITUTED SUBTILISIN FRAGMENT OF MANNOSE BINDING PROTEIN-A (SUB-MBP-A), MAD STRUCTURE AT 110K | Descriptor: | MANNOSE-BINDING PROTEIN A, YTTERBIUM (III) ION | Authors: | Burling, F.T, Weis, W.I, Flaherty, K.M, Brunger, A.T. | Deposit date: | 1995-11-09 | Release date: | 1996-06-10 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Direct observation of protein solvation and discrete disorder with experimental crystallographic phases. Science, 271, 1996
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1M6K
| Structure of the OXA-1 class D beta-lactamase | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, beta-lactamase OXA-1 | Authors: | Sun, T, Nukaga, M, Mayama, K, Braswell, E.H, Knox, J.R. | Deposit date: | 2002-07-16 | Release date: | 2003-01-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Comparison of beta-lactamases of classes A and D: 1.5A crystallographic structure of the class D OXA-1 oxacillinase PROTEIN SCI., 12, 2003
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2MSB
| STRUCTURE OF A C-TYPE MANNOSE-BINDING PROTEIN COMPLEXED WITH AN OLIGOSACCHARIDE | Descriptor: | CALCIUM ION, MANNOSE-BINDING PROTEIN-A, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Weis, W.I, Drickamer, K, Hendrickson, W.A. | Deposit date: | 1992-07-28 | Release date: | 1993-10-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature, 360, 1992
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