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6U28
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BU of 6u28 by Molmil
Crystal structure of 1918 NS1-ED W187A in complex with the p85-beta-iSH2 domain of human PI3K
Descriptor: Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Cho, J.H, Zhao, B, Savage, N, Li, P.
Deposit date:2019-08-19
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
1HDU
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BU of 1hdu by Molmil
Crystal structure of bovine pancreatic carboxypeptidase A complexed with aminocarbonylphenylalanine at 1.75 A
Descriptor: CARBOXYPEPTIDASE A, D-[(AMINO)CARBONYL]PHENYLALANINE, ZINC ION
Authors:Cho, J.H, Ha, N.-C, Chung, S.J, Kim, D.H, Choi, K.Y, Oh, B.-H.
Deposit date:2000-11-17
Release date:2001-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insight Into the Stereochemistry in the Inhibition of Carboxypeptidase a with N-(Hydroxyaminocarbonyl)Phenylalanine: Binding Modes of an Enantiomeric Pair of the Inhibitor to Carboxypeptidase A
Bioorg.Med.Chem., 10, 2002
1HEE
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BU of 1hee by Molmil
Crystal structure of bovine pancreatic carboxypeptidase A complexed with L-N-hydroxyaminocarbonyl phenylalanine at 2.3 A
Descriptor: CARBOXYPEPTIDASE A, L-[(N-HYDROXYAMINO)CARBONYL]PHENYLALANINE, ZINC ION
Authors:Cho, J.H, Ha, N.-C, Chung, S.J, Kim, D.H, Choi, K.Y, Oh, B.-H.
Deposit date:2000-11-22
Release date:2001-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insight Into the Stereochemistry in the Inhibition of Carboxypeptidase a with N-(Hydroxyaminocarbonyl)Phenylalanine: Binding Modes of an Enantiomeric Pair of the Inhibitor to Carboxypeptidase A
Bioorg.Med.Chem., 10, 2002
1HDQ
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BU of 1hdq by Molmil
Crystal structure of bovine pancreatic carboxypeptidase A complexed with D-N-hydroxyaminocarbonyl phenylalanine at 2.3 A
Descriptor: CARBOXYPEPTIDASE A, D-[(N-HYDROXYAMINO)CARBONYL]PHENYLALANINE, ZINC ION
Authors:Cho, J.H, Ha, N.-C, Chung, S.J, Kim, D.H, Choi, K.Y, Oh, B.-H.
Deposit date:2000-11-17
Release date:2001-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insight Into the Stereochemistry in the Inhibition of Carboxypeptidase a with N-(Hydroxyaminocarbonyl)Phenylalanine: Binding Modes of an Enantiomeric Pair of the Inhibitor to Carboxypeptidase A
Bioorg.Med.Chem., 10, 2002
6OX7
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BU of 6ox7 by Molmil
The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K
Descriptor: Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Shen, Q, Zhao, B, Li, P, Cho, J.H.
Deposit date:2019-05-13
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.
Proc.Natl.Acad.Sci.USA, 117, 2020
6NU0
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BU of 6nu0 by Molmil
Solution NMR structure of 1918 NS1 effector domain
Descriptor: Non-structural protein 1
Authors:Shen, Q, Cho, J.H.
Deposit date:2019-01-30
Release date:2020-01-08
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The structure and conformational plasticity of the nonstructural protein 1 of the 1918 influenza A virus.
Biochem.Biophys.Res.Commun., 518, 2019
6ATV
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BU of 6atv by Molmil
The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions
Descriptor: Adapter molecule crk, proline-rich motif in IAV-NS1
Authors:Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H.
Deposit date:2017-08-29
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Molecular Mechanisms of Tight Binding through Fuzzy Interactions.
Biophys. J., 114, 2018
7RCH
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BU of 7rch by Molmil
Crystal structure of NS1-ED of Vietnam influenza A virus in complex with the p85-beta-iSH2 domain of human PI3K
Descriptor: Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta
Authors:Kim, I, Zhao, B, Li, P, Cho, J.H.
Deposit date:2021-07-07
Release date:2022-07-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus.
Nat Commun, 13, 2022
5UL6
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BU of 5ul6 by Molmil
The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions
Descriptor: Adapter molecule crk, Proline-rich motif of nonstructural protein 1 of influenza a virus
Authors:Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H.
Deposit date:2017-01-24
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Molecular Mechanisms Underlying the Hijack of Host Proteins by the 1918 Spanish Influenza Virus.
ACS Chem. Biol., 12, 2017
2HVF
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BU of 2hvf by Molmil
Crystal Structure of N-terminal Domain of Ribosomal Protein L9 (NTL9), G34dA
Descriptor: 50S ribosomal protein L9, ACETIC ACID, CHLORIDE ION, ...
Authors:Anil, B, Kim, E.Y, Cho, J.H, Schindelin, H, Raleigh, D.P.
Deposit date:2006-07-28
Release date:2007-06-12
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Detecting and quantifying strain in protein folding
To be Published
5IJC
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BU of 5ijc by Molmil
The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte antigen 96, ...
Authors:Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B.
Deposit date:2016-03-01
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IJB
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BU of 5ijb by Molmil
The ligand-free structure of the mouse TLR4/MD-2 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte antigen 96, ...
Authors:Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B.
Deposit date:2016-03-01
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IJD
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BU of 5ijd by Molmil
The crystal structure of mouse TLR4/MD-2/lipid A complex
Descriptor: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B.
Deposit date:2016-03-01
Release date:2016-04-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
2WCS
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BU of 2wcs by Molmil
Crystal Structure of Debranching enzyme from Nostoc punctiforme (NPDE)
Descriptor: ALPHA AMYLASE, CATALYTIC REGION
Authors:Dumbrepatil, A.B, Choi, J.H, Nam, S.H, Park, K.H, Woo, E.J.
Deposit date:2009-03-16
Release date:2009-09-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Features of the Nostoc Punctiforme Debranching Enzyme Reveal the Basis of its Mechanism and Substrate Specificity.
Proteins, 78, 2010
2WKG
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BU of 2wkg by Molmil
Nostoc punctiforme Debranching Enzyme (NPDE)(Native form)
Descriptor: ALPHA AMYLASE, CATALYTIC REGION
Authors:Dumbrepatil, A.B, Choi, J.H, Song, H.N, Park, K.H, Woo, E.J.
Deposit date:2009-06-11
Release date:2009-09-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Features of the Nostoc Punctiforme Debranching Enzyme Reveal the Basis of its Mechanism and Substrate Specificity.
Proteins, 78, 2010
2HBA
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BU of 2hba by Molmil
Crystal Structure of N-terminal Domain of Ribosomal Protein L9 (NTL9) K12M
Descriptor: 50S ribosomal protein L9, CHLORIDE ION, IMIDAZOLE, ...
Authors:Cho, J.-H, Kim, E.Y, Schindelin, H, Raleigh, D.P.
Deposit date:2006-06-14
Release date:2007-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Energetically significant networks of coupled interactions within an unfolded protein.
Proc.Natl.Acad.Sci.USA, 111, 2014
2HBB
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BU of 2hbb by Molmil
Crystal Structure of the N-terminal Domain of Ribosomal Protein L9 (NTL9)
Descriptor: 50S ribosomal protein L9, ZINC ION
Authors:Cho, J.-H, Kim, E.Y, Schindelin, H, Raleigh, D.P.
Deposit date:2006-06-14
Release date:2007-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Energetically significant networks of coupled interactions within an unfolded protein.
Proc.Natl.Acad.Sci.USA, 111, 2014
1DG2
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BU of 1dg2 by Molmil
SOLUTION CONFORMATION OF A-CONOTOXIN AUIB
Descriptor: A-CONOTOXIN AUIB
Authors:Cho, J.-H, Mok, K.H, Olivera, B.M, McIntosh, J.M, Park, K.-H, Han, K.-H.
Deposit date:1999-11-23
Release date:2000-02-25
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist.
J.Biol.Chem., 275, 2000
5IH2
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BU of 5ih2 by Molmil
Structure, thermodynamics, and the role of conformational dynamics in the interactions between the N-terminal SH3 domain of CrkII and proline-rich motifs in cAbl
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Adapter molecule crk, DI(HYDROXYETHYL)ETHER, ...
Authors:Bhatt, V.S, Zeng, D, Krieger, I, Sacchettini, J.C, Cho, J.-H.
Deposit date:2016-02-28
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.
Biophys.J., 110, 2016
3R21
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BU of 3r21 by Molmil
Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
Descriptor: MAGNESIUM ION, N-(2-aminoethyl)-N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, Serine/threonine-protein kinase 6
Authors:Zhang, L, Fan, J, Chong, J.-H, Cesena, A, Tam, B, Gilson, C, Boykin, C, Wang, D, Marcotte, D, Le Brazidec, J.-Y, Aivazian, D, Piao, J, Lundgren, K, Hong, K, Vu, K, Nguyen, K.
Deposit date:2011-03-11
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
6IJQ
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BU of 6ijq by Molmil
Solution structure of BCL-XL bound to P73-TAD peptide
Descriptor: Bcl-2-like protein 1,Bcl-2-like protein 1, Tumor protein p73
Authors:Yoon, M.-K, Ha, J.-H, Lee, M.-S, Chi, S.-W.
Deposit date:2018-10-11
Release date:2018-11-21
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL.
J. Biol. Chem., 293, 2018
6VIK
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BU of 6vik by Molmil
Crystal structure of mouse xm RABL3 in complex with GTPgammsS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rab-like protein 3
Authors:Su, L, Tomchick, D.R, Beutler, B.
Deposit date:2020-01-13
Release date:2020-04-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VIH
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BU of 6vih by Molmil
The ligand-free structure of mouse RABL3
Descriptor: Rab-like protein 3
Authors:Su, L, Tomchick, D.R, Beutler, B.
Deposit date:2020-01-13
Release date:2020-04-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VIJ
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BU of 6vij by Molmil
Crystal structure of mouse RABL3 in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rab-like protein 3
Authors:Su, L, Tomchick, D.R, Beutler, B.
Deposit date:2020-01-13
Release date:2020-04-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.
Proc.Natl.Acad.Sci.USA, 117, 2020
4X7Q
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BU of 4x7q by Molmil
PIM2 kinase in complex with Compound 1s
Descriptor: 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, PHOSPHATE ION, Serine/threonine-protein kinase pim-2
Authors:Marcotte, D.J, Silvian, L.F.
Deposit date:2014-12-09
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015

 

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