5IJB

The ligand-free structure of the mouse TLR4/MD-2 complex

Replaces:  5HG3

Summary for 5IJB

• Entry DOI: 10.2210/pdb5ijb/pdb
• Related: 5LJC 5LJD
• Descriptor: Toll-like receptor 4, Variable lymphocyte receptor B chimera, Lymphocyte antigen 96, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: leucine-rich repeats, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 173220.65

Authors

Wang, Y.,Su, L.,Morin, M.D.,Jones, B.T.,Whitby, L.R.,Surakattula, M.,Huang, H.,Shi, H.,Choi, J.H.,Wang, K.,Moresco, E.M.,Berger, M.,Zhan, X.,Zhang, H.,Boger, D.L.,Beutler, B. (deposition date: 2016-03-01, release date: 2016-04-27, Last modification date: 2023-09-27)

• Primary citation: Wang, Y.,Su, L.,Morin, M.D.,Jones, B.T.,Whitby, L.R.,Surakattula, M.M.,Huang, H.,Shi, H.,Choi, J.H.,Wang, K.W.,Moresco, E.M.,Berger, M.,Zhan, X.,Zhang, H.,Boger, D.L.,Beutler, B.; TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.; Proc.Natl.Acad.Sci.USA, 113:E884-E893, 2016; PubMed: 26831104; DOI: 10.1073/pnas.1525639113

Experimental method

X-RAY DIFFRACTION (2.91 Å)