7RCH

Crystal structure of NS1-ED of Vietnam influenza A virus in complex with the p85-beta-iSH2 domain of human PI3K

Summary for 7RCH

• Entry DOI: 10.2210/pdb7rch/pdb
• Descriptor: Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta (2 entities in total)
• Functional Keywords: vietnam influenza a virus, ns1, pi3k, viral protein
• Biological source: Influenza A virus (A/Viet Nam/1203/2004(H5N1)); More
• Total number of polymer chains: 4
• Total formula weight: 68025.32

Authors

Kim, I.,Zhao, B.,Li, P.,Cho, J.H. (deposition date: 2021-07-07, release date: 2022-07-13, Last modification date: 2023-10-18)

• Primary citation: Kim, I.,Dubrow, A.,Zuniga, B.,Zhao, B.,Sherer, N.,Bastiray, A.,Li, P.,Cho, J.H.; Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus.; Nat Commun, 13:5775-5775, 2022; PubMed: 36182933; DOI: 10.1038/s41467-022-33554-9

Experimental method

X-RAY DIFFRACTION (3.1 Å)