7RCH

Crystal structure of NS1-ED of Vietnam influenza A virus in complex with the p85-beta-iSH2 domain of human PI3K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Non-structural protein 1	polymer	126	14103.2	2	UniProt (A5A5U1) Pfam (PF00600)	Influenza A virus (A/Viet Nam/1203/2004(H5N1))	NS1
2	B, D (C, D)	Phosphatidylinositol 3-kinase regulatory subunit beta	polymer	165	19909.5	2	UniProt (O00459) Pfam (PF16454)	Homo sapiens (Human)	PI3-kinase regulatory subunit beta,PI3K regulatory subunit beta,PtdIns-3-kinase regulatory subunit beta,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta,PI3-kinase subunit p85-beta,PtdIns-3-kinase regulatory subunit p85-beta

Sequence modifications

A, B: 81 - 206 (UniProt: A5A5U1)

PDB	External Database	Details
Ala 182	Trp 182	engineered mutation

C, D: 435 - 597 (UniProt: O00459)

PDB	External Database	Details
Gly 433	-	expression tag
Ser 434	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	68025.3
All*	Total formula weight	68025.3

*Water molecules are not included.