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2RH1
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BU of 2rh1 by Molmil
High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ...
Authors:Cherezov, V, Rosenbaum, D.M, Hanson, M.A, Rasmussen, S.G.F, Thian, F.S, Kobilka, T.S, Choi, H.J, Kuhn, P, Weis, W.I, Kobilka, B.K, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2007-10-05
Release date:2007-10-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
2VDF
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BU of 2vdf by Molmil
Structure of the OpcA adhesion from Neisseria meningitidis determined by crystallization from the cubic mesophase
Descriptor: N-OCTANE, OUTER MEMBRANE PROTEIN, SULFATE ION
Authors:Cherezov, V, Liu, W, Derrick, J.P, Luan, B, Aksimentiev, A, Katritch, V, Caffrey, M.
Deposit date:2007-10-05
Release date:2007-10-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin.
Proteins, 71, 2008
3BYR
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BU of 3byr by Molmil
Mode of Action of a Putative Zinc Transporter CzrB (Zn form)
Descriptor: CzrB protein, ZINC ION
Authors:Cherezov, V, Srinivasan, V, Szebenyi, D.M.E, Caffrey, M.
Deposit date:2008-01-16
Release date:2008-09-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus
Structure, 16, 2008
3BYP
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BU of 3byp by Molmil
Mode of Action of a Putative Zinc Transporter CzrB
Descriptor: CzrB protein, SULFATE ION
Authors:Cherezov, V, Srinivasan, V, Szebenyi, D.M.E, Caffrey, M.
Deposit date:2008-01-16
Release date:2008-09-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus
Structure, 16, 2008
7JNI
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BU of 7jni by Molmil
Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, HEXANE-1,6-DIOL, ...
Authors:Cherezov, V, Shaye, H, Han, G.W.
Deposit date:2020-08-04
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma.
Proc.Natl.Acad.Sci.USA, 119, 2022
2GUF
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BU of 2guf by Molmil
In meso crystal structure of the cobalamin transporter, BtuB
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, FORMIC ACID, Vitamin B12 transporter btuB, ...
Authors:Caffrey, M, Cherezov, V, Yamashita, E, Cramer, W.A.
Deposit date:2006-04-29
Release date:2006-12-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 A Resolution.
J.Mol.Biol., 364, 2006
2FKW
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BU of 2fkw by Molmil
Structure of LH2 from Rps. acidophila crystallized in lipidic mesophases
Descriptor: BACTERIOCHLOROPHYLL A, LAURYL DIMETHYLAMINE-N-OXIDE, Light-harvesting protein B-800/850, ...
Authors:Papiz, M.Z, Cherezov, V, Clogston, J, Caffrey, M.
Deposit date:2006-01-05
Release date:2006-03-28
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases
J.Mol.Biol., 357, 2006
7YXA
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BU of 7yxa by Molmil
XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ...
Authors:Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V.
Deposit date:2022-02-15
Release date:2022-08-10
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors.
Nat Commun, 13, 2022
6B73
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BU of 6b73 by Molmil
Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor
Descriptor: CHOLESTEROL, N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide, Nanobody, ...
Authors:Che, T, Majumdar, S, Zaidi, S.A, Kormos, C, McCorvy, J.D, Wang, S, Mosier, P.D, Uprety, R, Vardy, E, Krumm, B.E, Han, G.W, Lee, M.Y, Pardon, E, Steyaert, J, Huang, X.P, Strachan, R.T, Tribo, A.R, Pasternak, G.W, Carroll, I.F, Stevens, R.C, Cherezov, V, Katritch, V, Wacker, D, Roth, B.L.
Deposit date:2017-10-03
Release date:2018-01-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell, 172, 2018
8TYW
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BU of 8tyw by Molmil
cryo-EM structure of GPR6-Gs-Nb35 complex
Descriptor: G-protein coupled receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Barekatain, M, Johansson, L.C, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, J, Hua, T, Katritch, V, Cherezov, V.
Deposit date:2023-08-26
Release date:2024-12-04
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
6MH8
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BU of 6mh8 by Molmil
High-viscosity injector-based Pink Beam Serial Crystallography of Micro-crystals at a Synchrotron Radiation Source
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a, Soluble cytochrome b562 chimeric construct
Authors:Martin-Garcia, J.M, Zhu, L, Mendez, D, Lee, M, Chun, E, Li, C, Hu, H, Subramanian, G, Kissick, D, Ogata, C, Henning, R, Ishchenko, A, Dobson, Z, Zhan, S, Weierstall, U, Spence, J.C.H, Fromme, P, Zatsepin, N.A, Fischetti, R.F, Cherezov, V, Liu, W.
Deposit date:2018-09-17
Release date:2019-04-24
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:High-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Iucrj, 6, 2019
8T1W
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BU of 8t1w by Molmil
Crystal structure of orphan G protein-coupled receptor 6 with bound CVN424
Descriptor: 1-{2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl}ethan-1-one, G-protein coupled receptor 6, Soluble cytochrome b562 chimera
Authors:Barekatain, M, Johansson, L, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, Z, Hua, T, Katritch, V, Cherezov, V.
Deposit date:2023-06-04
Release date:2024-12-04
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
8TF5
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BU of 8tf5 by Molmil
Crystal structure of orphan G protein-coupled receptor 6, pseudoapo form
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, CHOLESTEROL, ...
Authors:Barekatain, M, Johansson, L, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, Z, Hua, T, Katritch, V, Cherezov, V.
Deposit date:2023-07-07
Release date:2024-12-04
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
8T1V
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BU of 8t1v by Molmil
Crystal structure of orphan G protein-coupled receptor 6 with bound inverse agonist 3h
Descriptor: 3-{4-[(2,4-difluorophenyl)methyl]piperazin-1-yl}-7-methyl-N-(propan-2-yl)pyrido[3,4-b]pyrazin-2-amine, G-protein coupled receptor 6, Soluble cytochrome b562 chimera, ...
Authors:Barekatain, M, Johansson, L, Lam, J.H, Sadybekov, A.V, Han, G.W, Popov, P, Russo, J, Bliesath, J, Brice, N, Beresford, M, Carlson, L, Saikatendu, K.S, Sun, H, Murphy, S, Monenschein, H, Schiffer, H.H, Lutomski, C, Robinson, C.V, Liu, Z, Hua, T, Katritch, V, Cherezov, V.
Deposit date:2023-06-04
Release date:2024-12-04
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Sci.Signal., 17, 2024
6VJM
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BU of 6vjm by Molmil
Human metabotropic GABA(B) receptor in its apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shaye, H, Han, G.W, Gati, C, Cherezov, V.
Deposit date:2020-01-16
Release date:2020-06-10
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Structural basis of the activation of a metabotropic GABA receptor.
Nature, 584, 2020
6PNY
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BU of 6pny by Molmil
X-ray Structure of Flpp3
Descriptor: Flpp3
Authors:Zook, J.D, Shekhar, M, Hansen, D.T, Conrad, C, Grant, T.D, Gupta, C, White, T, Barty, A, Basu, S, Zhao, Y, Zatsepin, N.A, Ishchenko, A, Batyuk, A, Gati, C, Li, C, Galli, L, Coe, J, Hunter, M, Liang, M, Weierstall, U, Nelson, G, James, D, Stauch, B, Craciunescu, F, Thifault, D, Liu, W, Cherezov, V, Singharoy, A, Fromme, P.
Deposit date:2019-07-03
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.
Structure, 28, 2020
9IYA
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BU of 9iya by Molmil
Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex
Descriptor: 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide, G-protein coupled receptor 55,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ...
Authors:Hua, T, Liu, Z.J, Cherezov, V, Chang, H, Li, X.T, Shen, L.
Deposit date:2024-07-30
Release date:2025-01-01
Last modified:2025-01-22
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structure basis of ligand recognition and activation of GPR55.
Cell Res., 35, 2025
9IY8
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BU of 9iy8 by Molmil
Cryo-EM structure of apo-GPR55-G13 complex
Descriptor: G-protein coupled receptor 55, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Hua, T, Liu, Z.J, Cherezov, V, Chang, H, Li, X.T, Shen, L.
Deposit date:2024-07-30
Release date:2025-01-01
Last modified:2025-01-22
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structure basis of ligand recognition and activation of GPR55.
Cell Res., 35, 2025
3NYA
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BU of 3nya by Molmil
Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol
Descriptor: (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor, Lysozyme, ...
Authors:Brown, M.A, Wacker, D, Fenalti, G, Katritch, V, Abagyan, R, Cherezov, V, Stevens, R.C, GPCR Network (GPCR)
Deposit date:2010-07-14
Release date:2010-08-11
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
J.Am.Chem.Soc., 132, 2010
7M8W
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BU of 7m8w by Molmil
XFEL crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2
Descriptor: 15R-methyl-prostaglandin D2, CITRATE ANION, Prostaglandin D2 receptor 2, ...
Authors:Shiriaeva, A, Han, G.W, Cherezov, V.
Deposit date:2021-03-30
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Molecular basis for lipid recognition by the prostaglandin D 2 receptor CRTH2.
Proc.Natl.Acad.Sci.USA, 118, 2021
5XF1
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BU of 5xf1 by Molmil
Structure of the Full-length glucagon class B G protein-coupled receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
8VHF
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BU of 8vhf by Molmil
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Descriptor: 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kim, D.-G, Cherezov, V.
Deposit date:2024-01-01
Release date:2024-10-30
Last modified:2025-03-05
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination.
Structure, 32, 2024
5XEZ
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BU of 5xez by Molmil
Structure of the Full-length glucagon class B G protein-coupled receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, ...
Authors:Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
3S8F
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BU of 3s8f by Molmil
1.8 A structure of ba3 cytochrome c oxidase from Thermus thermophilus in lipid environment
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ...
Authors:Tiefenbrunn, T, Liu, W, Chen, Y, Katritch, V, Stout, C.D, Fee, J.A, Cherezov, V.
Deposit date:2011-05-27
Release date:2011-08-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.
Plos One, 6, 2011
3S8G
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BU of 3s8g by Molmil
1.8 A structure of ba3 cytochrome c oxidase mutant (A120F) from Thermus thermophilus in lipid environment
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ...
Authors:Tiefenbrunn, T, Liu, W, Chen, Y, Katritch, V, Stout, C.D, Fee, J.A, Cherezov, V.
Deposit date:2011-05-27
Release date:2011-08-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.
Plos One, 6, 2011

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