Author results

202D
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SOLUTION STRUCTURE OF THE MENOGARIL-DNA COMPLEX
Descriptor:DNA (5'-D(*GP*AP*CP*AP*TP*GP*TP*C)-3'), MENOGARIL
Authors:Chen, H., Patel, D.J.
Deposit date:1995-03-29
Release date:1995-06-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Menogaril-DNA Complex
J.Am.Chem.Soc., 117, 1995
4IQ2
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P21 CRYSTAL FORM OF FKBP12.6
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP1B, MALONIC ACID
Authors:Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G.
Deposit date:2013-01-10
Release date:2014-01-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
4IQC
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P3121 CRYSTAL FORM OF FKBP12.6
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP1B
Authors:Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G.
Deposit date:2013-01-11
Release date:2014-01-15
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
193D
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SOLUTION STRUCTURE OF A QUINOMYCIN BISINTERCALATOR-DNA COMPLEX
Descriptor:DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*T)-3'), QUINOMYCIN, 3-HYDROXYQUINALDIC ACID
Authors:Chen, H., Patel, D.J.
Deposit date:1994-09-30
Release date:1995-02-27
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:Solution Structure of a Quinomycin Bisintercalator-DNA Complex.
J.Mol.Biol., 246, 1995
1FJA
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NMR STUDY OF DEOXYRIBONUCLEIC ACID COMPLEXED WITH ACTINOMYCIN D
Descriptor:DNA (5'-D(*AP*AP*GP*CP*GP*CP*TP*T)-3'), ACTINOMYCIN D
Authors:Chen, H., Liu, X., Patel, D.J.
Deposit date:1995-12-15
Release date:1996-06-10
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:DNA Bending and Unwinding Associated with Actinomycin D Antibiotics Bound to Partially Overlapping Sites on DNA.
J.Mol.Biol., 258, 1996
1FJB
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NMR STUDY OF AN 11-MER DNA DUPLEX CONTAINING 7,8-DIHYDRO-8-OXOADENINE (AOXO) OPPOSITE THYMINE
Descriptor:DNA (5'-D(*GP*CP*AP*TP*GP*TP*GP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*CP*(A38)P*CP*AP*TP*GP*C)-3')
Authors:Chen, H., Johnson, F., Grollman, A.P., Patel, D.J.
Deposit date:1995-12-15
Release date:1996-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Studies of the Ionizing Radiation Adduct 7,8-Dihydro-8-Oxoadenine (A Oxo) Positioned Opposite Thymine and Guanine in DNA Duplexes
MAGN.RESON.CHEM., 34, 1996
2PSQ
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CRYSTAL STRUCTURE OF UNPHOSPHORYLATED UNACTIVATED WILD TYPE FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-07
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVF
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CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED ACTIVATED FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN IN COMPLEX WITH ATP ANALOG AND SUBSTRATE PEPTIDE
Descriptor:Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-09
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVY
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K659N MUTATION RESPONSIBLE FOR AN UNCLASSIFIED CRANIOSYNOSTOSIS SYNDROME.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-10
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PWL
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549H MUTATION RESPONSIBLE FOR CROUZON SYNDROME.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-11
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PY3
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565G MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, MAGNESIUM ION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-15
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZ5
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC N549T MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, MAGNESIUM ION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-17
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZP
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K526E MUTATION RESPONSIBLE FOR CROUZON SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, MAGNESIUM ION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZR
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K641R MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2Q0B
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC E565A MUTATION RESPONSIBLE FOR PFEIFFER SYNDROME
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2007-05-21
Release date:2007-09-25
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
3CLY
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAINS TRAPPED IN TRANS-PHOSPHORYLATION REACTION
Descriptor:Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H., Mohammadi, M.
Deposit date:2008-03-20
Release date:2009-02-03
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:A crystallographic snapshot of tyrosine trans-phosphorylation in action
Proc.Natl.Acad.Sci.USA, 105, 2008
3E17
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CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN FROM HUMAN ZONA OCCLUDENS-2
Descriptor:Tight junction protein ZO-2
Authors:Chen, H., Tong, S.L., Teng, M.K., Niu, L.W.
Deposit date:2008-08-01
Release date:2009-07-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the second PDZ domain from human zonula occludens 2
Acta Crystallogr.,Sect.F, 65, 2009
3MEX
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CRYSTAL STRUCTURE OF MEXR IN OXIDIZED STATE
Descriptor:Multidrug resistance operon repressor
Authors:Chen, H., Yi, C., Zhang, J., Zhang, W., Yang, C.-G., He, C.
Deposit date:2010-04-01
Release date:2010-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR
Embo Rep., 11, 2010
4DM4
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THE CONSERVED DOMAIN OF YEAST CDC73
Descriptor:Cell division control protein 73
Authors:Chen, H., Shi, N., Gao, Y., Li, X., Niu, L., Teng, M.
Deposit date:2012-02-06
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold.
Acta Crystallogr.,Sect.D, 68, 2012
4J95
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC K659N MUTATION RESPONSIBLE FOR AN UNCLASSIFIED CRANIOSYNOSTOSIS SYNDROME IN SPACE GROUP C2.
Descriptor:Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H., Mohammadi, M.
Deposit date:2013-02-15
Release date:2013-08-07
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.3767 Å)
Cite:Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J96
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC GAIN-OF-FUNCTION K659M MUTATION IDENTIFIED IN CERVICAL CANCER.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, CITRATE ANION, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2013-02-15
Release date:2013-08-07
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.2972 Å)
Cite:Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J97
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE PATHOGENIC GAIN-OF-FUNCTION K659E MUTATION IDENTIFIED IN ENDOMETRIAL CANCER.
Descriptor:Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H., Mohammadi, M.
Deposit date:2013-02-15
Release date:2013-08-07
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.5482 Å)
Cite:Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J99
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CRYSTAL STRUCTURE OF FGF RECEPTOR 2 (FGFR2) KINASE DOMAIN HARBORING THE GAIN-OF-FUNCTION K659T MUTATION.
Descriptor:Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H., Mohammadi, M.
Deposit date:2013-02-15
Release date:2013-08-07
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.8474 Å)
Cite:Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
5BYY
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ERK5 IN COMPLEX WITH SMALL MOLECULE
Descriptor:Mitogen-activated protein kinase 7, 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Authors:Chen, H., Tucker, J., Wang, X., Gavine, P.R., Philips, C., Augustin, M.A., Schreiner, P., Steinbacher, S., Preston, M., Ogg, D.
Deposit date:2015-06-11
Release date:2016-05-04
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
5BYZ
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ERK5 IN COMPLEX WITH SMALL MOLECULE
Descriptor:Mitogen-activated protein kinase 7, 4-({5-fluoro-4-[2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)-N-[2-(piperidin-1-yl)ethyl]benzamide, GLYCEROL
Authors:Chen, H., Tucker, J., Wang, X., Gavine, P.R., Philips, C., Augustin, M.A., Schreiner, P., Steinbacher, S., Preston, M., Ogg, D.
Deposit date:2015-06-11
Release date:2016-05-04
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
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