Author results

1RFF
  • Download 1rff
  • View 1rff
Molmil generated image of 1rff
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTAPEPTIDE KLNYYDPR, AND TETRANUCLEOTIDE AGTT.
Descriptor:5'-D(*AP*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-08
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RFI
  • Download 1rfi
  • View 1rfi
Molmil generated image of 1rfi
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, PENTAPEPTIDE KLNYK, AND TETRANUCLEOTIDE AGTC
Descriptor:5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RG1
  • Download 1rg1
  • View 1rg1
Molmil generated image of 1rg1
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTT
Descriptor:5'-D(*AP*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RG2
  • Download 1rg2
  • View 1rg2
Molmil generated image of 1rg2
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTA
Descriptor:5'-D(*AP*GP*TP*A)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-11
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RGU
  • Download 1rgu
  • View 1rgu
Molmil generated image of 1rgu
THE CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTG
Descriptor:5'-D(*AP*GP*TP*G)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-13
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RH0
  • Download 1rh0
  • View 1rh0
Molmil generated image of 1rh0
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE AND TRINUCLEOTIDE GTT
Descriptor:5'-D(*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-13
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RGT
  • Download 1rgt
  • View 1rgt
Molmil generated image of 1rgt
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTC
Descriptor:5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-12
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1NOP
  • Download 1nop
  • View 1nop
Molmil generated image of 1nop
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1) IN COMPLEX WITH VANADATE, DNA AND A HUMAN TOPOISOMERASE I-DERIVED PEPTIDE
Descriptor:5'-D(*AP*GP*AP*GP*TP*T)-3', tyrosyl-DNA phosphodiesterase 1, topoisomerase I-derived peptide, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2003-01-16
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide
Chem.Biol., 10, 2003
1MU7
  • Download 1mu7
  • View 1mu7
Molmil generated image of 1mu7
CRYSTAL STRUCTURE OF A HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)-TUNGSTATE COMPLEX
Descriptor:Tyrosyl-DNA Phosphodiesterase, TUNGSTATE(VI)ION, GLYCEROL
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2002-09-23
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights Into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures
J.Mol.Biol., 324, 2003
1MU9
  • Download 1mu9
  • View 1mu9
Molmil generated image of 1mu9
CRYSTAL STRUCTURE OF A HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)-VANADATE COMPLEX
Descriptor:Tyrosyl-DNA Phosphodiesterase, VANADATE ION, GLYCEROL
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2002-09-23
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Insights Into Substrate Binding and Catalytic Mechanism of Human Tyrosyl-DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures
J.Mol.Biol., 324, 2002
1A31
  • Download 1a31
  • View 1a31
Molmil generated image of 1a31
HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.J.
Deposit date:1998-01-27
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1A35
  • Download 1a35
  • View 1a35
Molmil generated image of 1a35
HUMAN TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.
Deposit date:1998-01-29
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1A36
  • Download 1a36
  • View 1a36
Molmil generated image of 1a36
TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I
Authors:Stewart, L., Redinbo, M.R., Qiu, X., Champoux, J.J., Hol, W.G.J.
Deposit date:1998-01-29
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A model for the mechanism of human topoisomerase I.
Science, 279, 1998
1EJ9
  • Download 1ej9
  • View 1ej9
Molmil generated image of 1ej9
CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Descriptor:DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I
Authors:Redinbo, M.R., Champoux, J.J., Hol, W.G.
Deposit date:2000-03-01
Release date:2000-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
Biochemistry, 39, 2000
1JY1
  • Download 1jy1
  • View 1jy1
Molmil generated image of 1jy1
CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1)
Descriptor:TYROSYL-DNA PHOSPHODIESTERASE
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.J.
Deposit date:2001-09-10
Release date:2002-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1.
Structure, 10, 2002
1R49
  • Download 1r49
  • View 1r49
Molmil generated image of 1r49
HUMAN TOPOISOMERASE I (TOPO70) DOUBLE MUTANT K532R/Y723F
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I
Authors:Interthal, H., Quigley, P.M., Hol, W.G., Champoux, J.J.
Deposit date:2003-10-03
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
J.Biol.Chem., 279, 2004
2B9S
  • Download 2b9s
  • View 2b9s
Molmil generated image of 2b9s
CRYSTAL STRUCTURE OF HETERODIMERIC L. DONOVANI TOPOISOMERASE I-VANADATE-DNA COMPLEX
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ...
Authors:Davies, D.R., Hol, W.G.J.
Deposit date:2005-10-12
Release date:2006-01-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
J.Mol.Biol., 357, 2006
1GTC
  • Download 1gtc
  • View 1gtc
Molmil generated image of 1gtc
HUMAN IMMUNODEFICIENCY VIRUS-1 OKAZAKI FRAGMENT, DNA-RNA CHIMERA, NMR, 11 STRUCTURES
Descriptor:DNA (5'-D(*GP*CP*AP*GP*TP*GP*GP*C)-3'), DNA/RNA (5'-R(*GP*CP*CP*A)-D(P*CP*TP*GP*C)-3')
Authors:Fedoroff, O.Y., Salazar, M., Reid, B.R.
Deposit date:1996-06-13
Release date:1996-12-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural variation among retroviral primer-DNA junctions: solution structure of the HIV-1 (-)-strand Okazaki fragment r(gcca)d(CTGC).d(GCAGTGGC).
Biochemistry, 35, 1996