1RG2
Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTA
Summary for 1RG2
| Entry DOI | 10.2210/pdb1rg2/pdb |
| Related | 1JY1 1NOP 1RFF 1RFI 1RG1 1RGT 1RGU 1RH0 |
| Descriptor | 5'-D(*AP*GP*TP*A)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... (7 entities in total) |
| Functional Keywords | protein-dna complex, vanadate complex, transition state mimic, hydrolase-dna complex, hydrolase/dna |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: Q9NUW8 |
| Total number of polymer chains | 4 |
| Total formula weight | 112937.03 |
| Authors | Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. (deposition date: 2003-11-11, release date: 2004-03-02, Last modification date: 2023-08-23) |
| Primary citation | Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem., 47:829-837, 2004 Cited by PubMed: 14761185DOI: 10.1021/jm030487x PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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