Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex

Summary for 2B9S

Descriptor5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (7 entities in total)
Functional Keywordstopoisomerase i, vanadate complex, isomerase-dna complex, isomerase/dna
Biological sourceLeishmania donovani
Total number of polymer chains5
Total molecular weight71607.03
Davies, D.R.,Hol, W.G.J. (deposition date: 2005-10-12, release date: 2006-01-17, Last modification date: 2017-10-11)
Primary citation
Davies, D.R.,Mushtaq, A.,Interthal, H.,Champoux, J.J.,Hol, W.G.
The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
J.Mol.Biol., 357:1202-1210, 2006
PubMed: 16487540 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2006.01.022
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.270303.3%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2b9s
no rotation
Molmil generated image of 2b9s
rotated about x axis by 90°
Molmil generated image of 2b9s
rotated about y axis by 90°