1RFI

Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, pentapeptide KLNYK, and tetranucleotide AGTC

Summary for 1RFI

• Entry DOI: 10.2210/pdb1rfi/pdb
• Related: 1JY1 1NOP 1RFF 1RG1 1RG2
• Descriptor: 5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ... (6 entities in total)
• Functional Keywords: protein-dna complex, vanadate complex, transition state mimic., hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9NUW8
• Total number of polymer chains: 6
• Total formula weight: 113609.89

Authors

Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. (deposition date: 2003-11-10, release date: 2004-03-02, Last modification date: 2024-02-14)

• Primary citation: Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G.; Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.; J.Med.Chem., 47:829-837, 2004; PubMed: 14761185; DOI: 10.1021/jm030487x

Experimental method

X-RAY DIFFRACTION (2.2 Å)