1RFI
Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, pentapeptide KLNYK, and tetranucleotide AGTC
Summary for 1RFI
Entry DOI | 10.2210/pdb1rfi/pdb |
Related | 1JY1 1NOP 1RFF 1RG1 1RG2 |
Descriptor | 5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ... (6 entities in total) |
Functional Keywords | protein-dna complex, vanadate complex, transition state mimic., hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9NUW8 |
Total number of polymer chains | 6 |
Total formula weight | 113609.89 |
Authors | Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. (deposition date: 2003-11-10, release date: 2004-03-02, Last modification date: 2024-02-14) |
Primary citation | Davies, D.R.,Interthal, H.,Champoux, J.J.,Hol, W.G. Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J.Med.Chem., 47:829-837, 2004 Cited by PubMed: 14761185DOI: 10.1021/jm030487x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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