Author results

7C8V
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STRUCTURE OF SYBODY SR4 IN COMPLEX WITH THE SARS-COV-2 S RECEPTOR BINDING DOMAIN (RBD)
Descriptor:Synthetic nanobody SR4, Spike glycoprotein, GLYCEROL, ...
Authors:Li, T., Yao, H., Cai, H., Qin, W., Li, D.
Deposit date:2020-06-03
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutratlization
To Be Published
7C8W
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STRUCTURE OF SYBODY MR17 IN COMPLEX WITH THE SARS-COV-2 S RECEPTOR-BINDING DOMAIN (RBD)
Descriptor:Synthetic nanobody MR17, Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Li, T., Cai, H., Yao, H., Qin, W., Li, D.
Deposit date:2020-06-03
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Rapid selection of synthetic nanobodies against the receptor binding domain of SARS-CoV-2 S protein
To Be Published
7CAN
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STRUCTURE OF SYBODY MR17-K99Y IN COMPLEX WITH THE SARS-COV-2 S RECEPTOR-BINDING DOMAIN (RBD)
Descriptor:sybody MR17-K99Y, Spike glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Li, T., Yao, H., Cai, H., Qin, W., Li, D.
Deposit date:2020-06-09
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutratlization
To Be Published
1C2T
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NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLASE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID.
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID, GLYCINAMIDE RIBONUCLEOTIDE
Authors:Greasley, S.E., Yamashita, M.M., Cai, H., Benkovic, S.J., Boger, D.L., Wilson, I.A.
Deposit date:1999-07-26
Release date:2000-01-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
Biochemistry, 38, 1999
1C3E
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NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLATE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID.
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, 2-{4-[2-(2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL)-1-CARBOXY-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, GLYCINAMIDE RIBONUCLEOTIDE
Authors:Greasley, S.E., Yamashita, M.M., Cai, H., Benkovic, S.J., Boger, D.L., Wilson, I.A.
Deposit date:1999-07-27
Release date:1999-12-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
Biochemistry, 38, 1999
1JKX
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UNEXPECTED FORMATION OF AN EPOXIDE-DERIVED MULTISUBSTRATE ADDUCT INHIBITOR ON THE ACTIVE SITE OF GAR TRANSFORMYLASE
Descriptor:PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE
Authors:Greasley, S.E., Marsilje, T.H., Cai, H., Baker, S., Benkovic, S.J., Boger, D.L., Wilson, I.A.
Deposit date:2001-07-13
Release date:2001-11-30
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
Biochemistry, 40, 2001
3BJ1
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MET-PERCH HEMOGLOBIN AT PH 5.7
Descriptor:hemoglobin alpha, hemoglobin beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Aranda IV, R., Cai, H., Levin, E.J., Richards, M.P., Phillips Jr., G.N.
Deposit date:2007-12-02
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
3BJ2
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MET-PERCH HEMOGLOBIN AT PH 6.3
Descriptor:hemoglobin alpha, hemoglobin beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Aranda IV, R., Cai, H., Levin, E.J., Richards, M.P., Phillips Jr., G.N.
Deposit date:2007-12-02
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
3BJ3
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MET-PERCH HEMOGLOBIN AT PH 8.0
Descriptor:hemoglobin alpha, hemoglobin beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Aranda IV, R., Cai, H., Levin, E.J., Richards, M.P., Phillips Jr., G.N.
Deposit date:2007-12-02
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
3CUE
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CRYSTAL STRUCTURE OF A TRAPP SUBASSEMBLY ACTIVATING THE RAB YPT1P
Descriptor:Transport protein particle 23 kDa subunit, Transport protein particle 31 kDa subunit, Transport protein particle 18 kDa subunit, ...
Authors:Cai, Y., Reinisch, K.M.
Deposit date:2008-04-16
Release date:2008-07-08
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.
Cell(Cambridge,Mass.), 133, 2008
5INW
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STRUCTURE OF REACTION LOOP CLEAVED LAMPREY ANGIOTENSINOGEN
Descriptor:Putative angiotensinogen, C-terminal peptide of Putative angiotensinogen, SULFATE ION
Authors:Wei, H., Zhou, A.
Deposit date:2016-03-08
Release date:2016-10-05
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016
5JDR
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STRUCTURE OF PD-L1
Descriptor:Programmed cell death 1 ligand 1
Authors:Zhou, A., Wei, H.
Deposit date:2016-04-17
Release date:2017-04-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Cell Discov, 3, 2017
5JDS
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CRYSTAL STRUCTURE OF PD-L1 COMPLEXED WITH A NANOBODY AT 1.7 ANGSTRON RESOLUTION
Descriptor:Nanobody, Programmed cell death 1 ligand 1, SODIUM ION, ...
Authors:Zhou, A., Wei, H.
Deposit date:2016-04-17
Release date:2017-04-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade.
Cell Discov, 3, 2017
4N5T
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THE 1.7A CRYSTAL STRUCTURE OF MDMX WITH A STAPLED PEPTIDE, ATSP-7041
Descriptor:Protein Mdm4, ATSP-7041 stapled-peptide
Authors:Graves, B.J., Lukacs, C., Janson, C.A.
Deposit date:2013-10-10
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc.Natl.Acad.Sci.USA, 110, 2013
5UD9
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CRYSTAL STRUCTURE OF 354BG18 FAB
Descriptor:Fab heavy chain, Light chain
Authors:Scharf, L., Bjorkman, P.J.
Deposit date:2016-12-23
Release date:2017-02-01
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
5UEL
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CRYSTAL STRUCTURE OF 354NC102 FAB
Descriptor:354NC102 Fab Heavy Chain, 354NC102 Fab Light Chain, SULFATE ION
Authors:Sievers, S.A., Gristick, H.B., Bjorkman, P.J.
Deposit date:2017-01-02
Release date:2017-02-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
5UEM
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CRYSTAL STRUCTURE OF 354NC37 FAB IN COMPLEX WITH HIV-1 CLADE AE STRAIN 93TH057 GP120
Descriptor:clade A/E 93TH057 HIV-1 gp120 core, 354NC37 Fab Heavy Chain, 354NC37 Fab Light Chain, ...
Authors:Sievers, S.A., Gristick, H.B., Bjorkman, P.J.
Deposit date:2017-01-02
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
2QSP
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BOVINE HEMOGLOBIN AT PH 5.7
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE
Authors:Aranda IV, R., Richards, M.P., Phillips Jr., G.N.
Deposit date:2007-07-31
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
2QSS
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BOVINE HEMOGLOBIN AT PH 6.3
Descriptor:Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ...
Authors:Aranda IV, R., Richards, M.P., Phillips Jr., G.N.
Deposit date:2007-07-31
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
2R1H
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MET-TROUT IV HEMOGLOBIN AT PH 6.3
Descriptor:Hemoglobin subunit alpha-4, Hemoglobin subunit beta-4, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Aranda IV, R., Worley, C.E., Richards, M.P., Phillips Jr., G.N.
Deposit date:2007-08-22
Release date:2008-09-02
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss.
Proteins, 75, 2008
5UUT
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N-MYRISTOYLTRANSFERASE 1 (NMT) BOUND TO MYRISTOYL-COA
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, CITRIC ACID
Authors:Goodwin, O., Pegan, S.
Deposit date:2017-02-17
Release date:2018-01-17
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.252 Å)
Cite:Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.
Cancer Res., 77, 2017
5XXY
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CRYSTAL STRUCTURE OF PD-L1 COMPLEXED WITH ATEZOLIZUMAB FAB AT 2.9A
Descriptor:heavy chain of atezolizumab fab, light chain of atezolizumab fab, Programmed cell death 1 ligand 1
Authors:Zhou, A., Zhang, F.
Deposit date:2017-07-05
Release date:2017-09-20
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of the therapeutic anti-PD-L1 antibody atezolizumab.
Oncotarget, 8, 2017
1DSI
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SOLUTION STRUCTURE OF A DUOCARMYCIN SA-INDOLE-ALKYLATED DNA DUPLEX
Descriptor:DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3'), 4-HYDROXY-6-(1H-INDOLE-2-CARBONYL)-8-METHYL-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER
Authors:Schnell, J.R., Ketchem, R.R., Boger, D.L., Chazin, W.J.
Deposit date:1998-07-29
Release date:1998-08-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct
J.Am.Chem.Soc., 121, 1999