Author results

2XDP
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CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN JMJD2C
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4C, SULFATE ION
Authors:Yue, W.W., Gileadi, C., Krojer, T., Weisbach, H., Ugochukwu, E., Daniel, M., Phillips, C., Chaikuad, A., von Delft, F., Allerston, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-05-06
Release date:2010-06-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal Structure of the Tudor Domain of Human Jmjd2C
To be Published
2VNA
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STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1)
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U.
Deposit date:2008-02-01
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
To be Published
2VSP
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CRYSTAL STRUCTURE OF THE FOURTH PDZ DOMAIN OF PDZ DOMAIN-CONTAINING PROTEIN 1
Descriptor:PDZ DOMAIN-CONTAINING PROTEIN 1
Authors:Yue, W.W., Shafqat, N., Pilka, E.S., Johansson, C., Murray, J.W., Elkins, J., Roos, A., Cooper, C., Phillips, C., Salah, E., von Delft, F., Doyle, D., Edwards, A., Wikstrom, M., Arrowsmith, C., Bountra, C., Oppermann, U.
Deposit date:2008-04-28
Release date:2009-03-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of the Fourth Pdz Domain of Pdz Domain-Containing Protein 1
To be Published
2VZ5
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STRUCTURE OF THE PDZ DOMAIN OF TAX1 (HUMAN T-CELL LEUKEMIA VIRUS TYPE I) BINDING PROTEIN 3
Descriptor:TAX1-BINDING PROTEIN 3, IMIDAZOLE, ZINC ION, ...
Authors:Murray, J.W., Shafqat, N., Yue, W., Pilka, E., Johannsson, C., Salah, E., Cooper, C., Elkins, J.M., Pike, A.C., Roos, A., Filippakopoulos, P., von Delft, F., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Oppermann, U.
Deposit date:2008-07-30
Release date:2008-08-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.738 Å)
Cite:The Structure of the Pdz Domain of Tax1BP
To be Published
2W4F
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CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF HUMAN SCRIB1
Descriptor:PROTEIN LAP4, 1,2-ETHANEDIOL
Authors:Hozjan, V., Pilka, E.S., Roos, A.K., W Yue, W., Phillips, C., Bray, J., Cooper, C., Salah, E., Elkins, J.M., Muniz, J.R.C., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Bountra, C., Doyle, D.A., Oppermann, U.
Deposit date:2008-11-25
Release date:2008-12-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal Structure of the First Pdz Domain of Human Scrib1
To be Published
2WM3
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CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1 IN COMPLEX WITH NIFLUMIC ACID
Descriptor:NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, ...
Authors:Bhatia, C., Yue, W.W., Niesen, F., Pilka, E., Ugochukwu, E., Savitsky, P., Hozjan, V., Roos, A.K., Filippakopoulos, P., von Delft, F., Heightman, T., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-06-29
Release date:2009-08-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Nmra-Like Family Domain Containing Protein 1 in Complex with Niflumic Acid
To be Published
2WMD
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CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1 IN COMPLEX WITH NADP AND 2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
Descriptor:NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1, 2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bhatia, C., Pilka, E., Niesen, F., Yue, W.W., Ugochukwu, E., Savitsky, P., Hozjan, V., Roos, A.K., Filippakopoulos, P., von Delft, F., Heightman, T., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-06-30
Release date:2009-07-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Nmra-Like Family Domain Containing Protein 1
To be Published
2X1H
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CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH RALOXIFENE
Descriptor:ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Shafqat, N., Yue, W.W., Pike, A.C.W., Niesen, F., Ugochukwu, E., Krojer, T., Chaikuad, A., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-12-24
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Raloxifene
To be Published
2X4D
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE LHPP
Descriptor:PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Vollmar, M., Gileadi, C., Guo, K., Savitsky, P., Muniz, J.R.C., Yue, W., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-01-29
Release date:2010-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal Structure of Human Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase Lhpp
To be Published
2X7H
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CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH FENOPROFEN
Descriptor:ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, FENOPROFEN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Vollmar, M., Chaikuad, A., Pike, A.C.W., von Delft, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-02-26
Release date:2010-12-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Fenoprofen
To be Published
2XST
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CRYSTAL STRUCTURE OF THE HUMAN LIPOCALIN 15
Descriptor:LIPOCALIN 15, 1,2-ETHANEDIOL
Authors:Muniz, J.R.C., Gileadi, C., Yue, W.W., Krojer, T., Ugochukwu, E., Phillips, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-09-30
Release date:2010-10-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal Structure of the Human Lipocalin 15
To be Published
2XZZ
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CRYSTAL STRUCTURE OF THE HUMAN TRANSGLUTAMINASE 1 BETA-BARREL DOMAIN
Descriptor:PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K
Authors:Vollmar, M., Krysztofinska, E., Krojer, T., Yue, W.W., Cooper, C., Kavanagh, K., Allerston, C., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-11-30
Release date:2011-01-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Human Transglutaminase 1 Beta-Barrel Domain
To be Published
2Y05
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CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE IN COMPLEX WITH NADP AND RALOXIFENE
Descriptor:PROSTAGLANDIN REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RALOXIFENE, ...
Authors:Yue, W.W., Shafqat, N., Krojer, T., Pike, A.C.W., von Delft, F., Sethi, R., Savitsky, P., Johansson, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-11-30
Release date:2011-01-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene
To be Published
2YAN
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CRYSTAL STRUCTURE OF THE SECOND GLUTAREDOXIN DOMAIN OF HUMAN TXNL2
Descriptor:GLUTAREDOXIN-3, 1,2-ETHANEDIOL, FE (III) ION, ...
Authors:Vollmar, M., Johansson, C., Cocking, R., Muniz, J.R.C., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2011-02-23
Release date:2011-11-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Second Glutaredoxin Domain of Human Txnl2
To be Published
2YPD
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CRYSTAL STRUCTURE OF THE JUMONJI DOMAIN OF HUMAN JUMONJI DOMAIN CONTAINING 1C PROTEIN
Descriptor:PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C, 2-(ETHYLMERCURI-THIO)-BENZOIC ACID, SODIUM ION
Authors:Vollmar, M., Johansson, C., Krojer, T., Berridge, G., Burgess-Brown, N., Strain-Damerell, C., Froese, S., Williams, E., Goubin, S., Coutandin, D., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2012-10-30
Release date:2012-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Jumonji Domain of Human Jumonji Domain Containing 1C Protein
To be Published
3CE7
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CRYSTAL STRUCTURE OF TOXOPLASMA SPECIFIC MITOCHONDRIAL ACYL CARRIER PROTEIN, 59.M03510
Descriptor:Specific mitochondrial acyl carrier protein
Authors:Wernimont, A.K., Dong, A., Yang, C., Khuu, C., Lam, A., Brand, V., Kozieradzki, I., Cossar, D., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Weigelt, J., Bochkarev, A., Hui, R., Qiu, W., Structural Genomics Consortium (SGC)
Deposit date:2008-02-28
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of toxoplasma specific mitochondrial acyl carrier protein, 59.m03510.
To be Published
3MDY
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN COMPLEX WITH FKBP12 AND LDN-193189
Descriptor:Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Authors:Chaikuad, A., Sanvitale, C., Mahajan, P., Daga, N., Cooper, C., Krojer, T., Alfano, I., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
To be Published
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
3OOM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00507
Descriptor:Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
3OP3
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CRYSTAL STRUCTURE OF CELL DIVISION CYCLE 25C PROTEIN ISOFORM A FROM HOMO SAPIENS
Descriptor:M-phase inducer phosphatase 3, SULFATE ION
Authors:Kim, Y., Weger, A., Hatzos, C., Savitsky, P., Johansson, C., Ball, L., Barr, A., Vollmar, M., Muniz, J., Weigelt, J., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O., von Delft, F., Knapp, S., Joachimiak, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens
TO BE PUBLISHED
3P1M
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CRYSTAL STRUCTURE OF HUMAN FERREDOXIN-1 (FDX1) IN COMPLEX WITH IRON-SULFUR CLUSTER
Descriptor:Adrenodoxin, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Chaikuad, A., Johansson, C., Krojer, T., Yue, W.W., Phillips, C., Bray, J.E., Pike, A.C.W., Muniz, J.R.C., Vollmar, M., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Kavanagh, K., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structure of human ferredoxin-1 (FDX1) in complex with iron-sulfur cluster
To be Published
3PRY
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETA REFINED AT 2.3 A RESOLUTION
Descriptor:Heat shock protein HSP 90-beta, SULFATE ION, GLYCEROL, ...
Authors:Chaikuad, A., Pilka, E., Sharpe, T.D., Cooper, C.D.O., Phillips, C., Berridge, G., Ayinampudi, V., Fedorov, O., Keates, T., Thangaratnarajah, C., Zimmermann, T., Vollmar, M., Yue, W.W., Che, K.H., Krojer, T., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
3QIR
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CRYSTAL STRUCTURE OF PIWIL2 PAZ DOMAIN
Descriptor:Piwi-like protein 2
Authors:Dong, A., Xu, C., Bian, C., Wernimont, A.K., Kania, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2011-01-27
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of PIWIL2 PAZ domain
To be Published
3RCO
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CRYSTAL STRUCTURE OF A CONSERVED MOTIF IN HUMAN TDRD7
Descriptor:Tudor domain-containing protein 7, CHLORIDE ION
Authors:Dong, A., Xu, C., Walker, J.R., Lam, R., Guo, Y., Bian, C., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2011-03-31
Release date:2012-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a conserved motif in human TDRD7
To be Published
3T7L
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CRYSTAL STRUCTURE OF THE FYVE DOMAIN OF ENDOFIN (ZFYVE16) AT 1.1A RESOLUTION
Descriptor:Zinc finger FYVE domain-containing protein 16, ZINC ION, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Williams, E., Guo, K., Sanvitale, C., Berridge, G., Krojer, T., Muniz, J.R.C., Canning, P., Phillips, C., Shrestha, A., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2011-07-30
Release date:2011-08-31
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution
To be Published