6P0R

Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor

Summary for 6P0R

• Entry DOI: 10.2210/pdb6p0r/pdb
• Descriptor: Histone-lysine N-methyltransferase SUV39H2, (3S)-1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-N-[(pyridin-4-yl)methyl]pyrrolidin-3-amine, ZINC ION, ... (5 entities in total)
• Functional Keywords: methyltransferase domain, suv39h2, ots186935, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69363.58

Authors

Halabelian, L.,Dong, A.,Zeng, H.,Loppnau, P.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2019-05-17, release date: 2019-05-29, Last modification date: 2023-10-11)

• Primary citation: Halabelian, L.,Dong, A.,Zeng, H.,Loppnau, P.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC); Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor; to be published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)