7A21
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2158
Summary for 7A21
Entry DOI | 10.2210/pdb7a21/pdb |
Descriptor | Activin receptor type I, 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor complex, receptor, signaling protein, bmp |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 70192.72 |
Authors | Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2020-08-14, release date: 2020-09-16, Last modification date: 2024-01-31) |
Primary citation | Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2153 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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