Author results

4J30
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STRUCTURE OF THE EFFECTOR - IMMUNITY SYSTEM TAE4 / TAI4 FROM SALMONELLA TYPHIMURIUM, SELENOMETHIONINE VARIANT
Descriptor:Putative cytoplasmic protein, Putative periplasmic protein, CITRATE ANION, ...
Authors:Benz, J., Reinstein, J., Meinhart, A.
Deposit date:2013-02-05
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium.
Plos One, 8, 2013
4J32
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STRUCTURE OF THE EFFECTOR - IMMUNITY SYSTEM TAE4 / TAI4 FROM SALMONELLA TYPHIMURIUM
Descriptor:Putative cytoplasmic protein, Putative periplasmic protein, CITRATE ANION, ...
Authors:Benz, J., Reinstein, J., Meinhart, A.
Deposit date:2013-02-05
Release date:2013-05-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonella typhimurium.
Plos One, 8, 2013
6ELE
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
Descriptor:fAB heavy chain, fAB light chain, 1,2-ETHANEDIOL, ...
Authors:Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
Deposit date:2017-09-28
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6ELJ
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
Descriptor:fAB heavy chain, fAB light chain
Authors:Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
Deposit date:2017-09-29
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6ELL
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
Descriptor:fAB heavy chain, fAB light chain
Authors:Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
Deposit date:2017-09-29
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
6EMJ
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FAB FRAGMENT. ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION MAKING IN ANTIBODY DRUG DISCOVERY
Descriptor:fAB heavy chain, fAb light chain, SODIUM ION
Authors:Benz, J., Weigand, S., Dengl, S., Schlothauer, T., Auer, J., Ehler, A., Kettenberger, H., Lorenz, S., Hirschheydt, T., Georges, G.
Deposit date:2017-10-02
Release date:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision making in antibody drug discovery
To Be Published
1QDE
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CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TRANSLATION INITIATION FACTOR 4A FROM SACCHAROMYCES CEREVISIAE-THE PROTOTYPE OF THE DEAD BOX PROTEIN FAMILY
Descriptor:TRANSLATION INITIATION FACTOR 4A, SULFATE ION
Authors:Benz, J., Trachsel, H., Baumann, U.
Deposit date:1999-05-20
Release date:2000-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Structure Fold.Des., 7, 1999
4FGD
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STRUCTURE OF THE EFFECTOR PROTEIN TSE1 FROM PSEUDOMONAS AERUGINOSA, SELENOMETHIONINE VARIANT
Descriptor:Tse1, THIOCYANATE ION, CHLORIDE ION
Authors:Benz, J., Sendlmeier, C., Barends, T.R.M., Meinhart, A.
Deposit date:2012-06-04
Release date:2012-06-20
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa.
Plos One, 7, 2012
4FGE
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STRUCTURE OF THE EFFECTOR PROTEIN TSE1 FROM PSEUDOMONAS AERUGINOSA
Descriptor:Tse1, CHLORIDE ION, THIOCYANATE ION, ...
Authors:Benz, J., Sendlmeier, C., Barends, T.R.M., Meinhart, A.
Deposit date:2012-06-04
Release date:2012-06-20
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa.
Plos One, 7, 2012
4FGI
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STRUCTURE OF THE EFFECTOR - IMMUNITY SYSTEM TSE1 / TSI1 FROM PSEUDOMONAS AERUGINOSA
Descriptor:Tse1, Tsi1
Authors:Benz, J., Sendlmeier, C., Barends, T.R.M., Meinhart, A.
Deposit date:2012-06-04
Release date:2012-06-20
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa.
Plos One, 7, 2012
2FVJ
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A NOVEL ANTI-ADIPOGENIC PARTIAL AGONIST OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPARG) RECRUITS PPARG-COACTIVATOR-1 ALPHA (PGC1A) BUT POTENTIATES INSULIN SIGNALING IN VITRO
Descriptor:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, ...
Authors:Benz, J., Burgermeister, E., Flament, A., Schnoebelen, A., Stihle, M., Gsell, B., Rufer, A., Ruf, A., Kuhn, B., Maerki, H.P., Mizrahi, J., Sebokova, E., Niesor, E., Meyer, M.
Deposit date:2006-01-31
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
Mol.Endocrinol., 20, 2006
5CSZ
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CRYSTAL STRUCTURE OF GANTENERUMAB FAB FRAGMENT IN COMPLEX WITH ABETA 1-11
Descriptor:GANTENERUMAB FAB FRAGMENT HEAVY CHAIN, GANTENERUMAB FAB FRAGMENT LIGHT CHAIN, Amyloid beta A4 protein, ...
Authors:Benz, J., Burger, D., Loetscher, H.R., Bohrmann, B.
Deposit date:2015-07-23
Release date:2015-08-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-Beta binding and elicits cell-mediated removal of human amyloid-Beta.
J. Alzheimers Dis., 28, 2012
3FEI
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DESIGN AND BIOLOGICAL EVALUATION OF NOVEL, BALANCED DUAL PPARA/G AGONISTS
Descriptor:Peroxisome proliferator-activated receptor alpha, Peptide motif 5 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid
Authors:Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M., Schlatter, D.
Deposit date:2008-11-30
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
3FEJ
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DESIGN AND BIOLOGICAL EVALUATION OF NOVEL, BALANCED DUAL PPARA/G AGONISTS
Descriptor:Peroxisome proliferator-activated receptor gamma, peptide motif 3 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid
Authors:Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Kuhn, B., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M.
Deposit date:2008-11-30
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
3G8I
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ALEGLITAZAR, A NEW, POTENT, AND BALANCED PPAR ALPHA/GAMMA AGONIST FOR THE TREATMENT OF TYPE II DIABETES
Descriptor:Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
Authors:Benz, J., Bernardeau, A., Binggeli, A., Blum, D., Boehringer, M., Grether, U., Hilpert, H., Kuhn, B., Maerki, H.P., Meyer, M., Puentener, K., Raab, S., Ruf, A., Schlatter, D., Gsell, B., Stihle, M., Mohr, P.
Deposit date:2009-02-12
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19, 2009
4LIQ
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CSF-1 RECEPTOR IN COMPLEX WITH THE FAB FRAGMENT OF RG7155
Descriptor:Macrophage colony-stimulating factor 1 receptor, Fab fragment RG7155 heavy chain, Fab fragment RG7155 light chain, ...
Authors:Benz, J., Gorr, I.H., Hertenberger, H., Ries, C.H.
Deposit date:2013-07-03
Release date:2014-06-18
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
Cancer Cell, 25, 2014
5DMG
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X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430)
Descriptor:RB86 antibody Fab fragment heavy chain, RB86 antibody Fab fragment light chain, Microtubule-associated protein
Authors:Benz, J., Lorenz, S., Georges, G., Jochner, A., Goepfert, U., Grueninger, F., Bujotzek, A.
Deposit date:2015-09-08
Release date:2015-12-16
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:VH-VL orientation prediction for antibody humanization candidate selection: A case study.
Mabs, 8, 2016
1CJA
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ACTIN-FRAGMIN KINASE, CATALYTIC DOMAIN FROM PHYSARUM POLYCEPHALUM
Descriptor:PROTEIN (ACTIN-FRAGMIN KINASE), ADENOSINE MONOPHOSPHATE
Authors:Steinbacher, S., Hof, P., Eichinger, L., Schleicher, M., Gettemans, J., Vandekerckhove, J., Huber, R., Benz, J.
Deposit date:1999-04-08
Release date:1999-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain.
EMBO J., 18, 1999
3ZKX
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TERNARY BACE2 XAPERONE COMPLEX
Descriptor:BETA-SECRETASE 2, XA4813, XA4815, ...
Authors:Kuglstatter, A., Banner, D.W., Benz, J., Bertschinger, J., Burger, D., Cuppuleri, S., Debulpaep, M., Gast, A., Grabulovski, D., Gsell, B., Hilpert, H., Huber, W., Kusznir, E., Laeremans, T., Matile, H., Rufer, A., Schlatter, D., Steyeart, J., Stihle, M., Thoma, R., Weber, M., Ruf, A.
Deposit date:2013-01-25
Release date:2013-05-29
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones
Acta Crystallogr.,Sect.D, 69, 2013
1W6J
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STRUCTURE OF HUMAN OSC IN COMPLEX WITH RO 48-8071
Descriptor:LANOSTEROL SYNTHASE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, B-OCTYLGLUCOSIDE, ...
Authors:Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
Deposit date:2004-08-18
Release date:2004-10-29
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1W6K
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STRUCTURE OF HUMAN OSC IN COMPLEX WITH LANOSTEROL
Descriptor:LANOSTEROL SYNTHASE, B-OCTYLGLUCOSIDE, LANOSTEROL
Authors:Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
Deposit date:2004-08-19
Release date:2004-10-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
2XBV
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(5-CHLORO-PYRIDIN-2-YL)-AMIDE]-4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
Authors:Banner, D.W., Benz, J., Schlatter, D., Anselm, L., Haap, W.
Deposit date:2010-04-15
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
2XBW
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-SULFAMOYL-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(4-CHLORO-PHENYL)-AMIDE] 4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
Authors:Banner, D.W., Benz, J., Schlatter, D., Thomi, S., Haap, W.
Deposit date:2010-04-15
Release date:2010-08-04
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
2XBX
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-METHANESULFONYL-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(4-CHLORO-PHENYL)-AMIDE] 4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
Authors:Banner, D.W., Benz, J., Schlatter, D., Haap, W.
Deposit date:2010-04-15
Release date:2010-08-04
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
2XBY
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FACTOR XA IN COMPLEX WITH A PYRROLIDINE-3,4-DICARBOXYLIC ACID INHIBITOR
Descriptor:ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, (3R,4R)-1-METHYLCARBAMOYLMETHYL-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(4-CHLORO-PHENYL)-AMIDE] 4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}, ...
Authors:Banner, D.W., Benz, J., Schlatter, D., Thomi, S., Haap, W.
Deposit date:2010-04-15
Release date:2010-08-04
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
Bioorg.Med.Chem., 20, 2010
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