7ZPG

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGAND

Summary for 7ZPG

Entry DOI	10.2210/pdb7zpg/pdb
Descriptor	Monoglyceride lipase, [(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-(2-bromanyl-3-methoxy-phenyl)methanone (3 entities in total)
Functional Keywords	alpha/beta hydrolase, hydrolase, serine esterase;
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35929.31
Authors	Kemble, A.,Hornsperger, B.,Ruf, I.,Richter, H.,Benz, J.,Kuhn, B.,Heer, D.,Wittwer, M.,Engelhardt, B.,Grether, U.,Collin, L.,Leibrock, L. (deposition date: 2022-04-27, release date: 2022-09-21)
Primary citation	Kemble, A.M.,Hornsperger, B.,Ruf, I.,Richter, H.,Benz, J.,Kuhn, B.,Heer, D.,Wittwer, M.,Engelhardt, B.,Grether, U.,Collin, L. A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature. Plos One, 17:e0268590-e0268590, 2022 Cited by PubMed: 36084029 DOI: 10.1371/journal.pone.0268590 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.16 Å)

Structure validation