3SGJ

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgIII and antibodies lacking core fucose

Summary for 3SGJ

• Entry DOI: 10.2210/pdb3sgj/pdb
• Related: 3SGK
• Descriptor: human Fc fragment, human Fcg3a receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: receptor complex, fc receptor, antibody, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 78421.64

Authors

Ferrara, C.,Grau, S.,Jaeger, C.,Sondermann, P.,Bruenker, P.,Waldhauer, I.,Hennig, M.,Ruf, A.,Rufer, A.C.,Stihle, M.,Umana, P.,Benz, J. (deposition date: 2011-06-15, release date: 2011-08-03, Last modification date: 2020-07-29)

• Primary citation: Ferrara, C.,Grau, S.,Jager, C.,Sondermann, P.,Brunker, P.,Waldhauer, I.,Hennig, M.,Ruf, A.,Rufer, A.C.,Stihle, M.,Umana, P.,Benz, J.; Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.; Proc.Natl.Acad.Sci.USA, 108:12669-12674, 2011; PubMed: 21768335; DOI: 10.1073/pnas.1108455108

Experimental method

X-RAY DIFFRACTION (2.2 Å)