6T13

CRYSTAL STRUCTURE OF GLUCOCEREBROSIDASE IN COMPLEX WITH A PYRROLOPYRAZINE

Summary for 6T13

Entry DOI	10.2210/pdb6t13/pdb
Descriptor	Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (10 entities in total)
Functional Keywords	gcase, glycosidase, cerezyme, hydrolysis, hydrolase, glycosylceramidase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	243175.56
Authors	Benz, J.,Ehler, A.,Hug, M.,Huber, S.,Rufer, A.C.,Guba, W.,Jagasia, R.,Hofmann, E.C.,Rodriguez Sarmiento, R.M. (deposition date: 2019-10-03, release date: 2020-12-23, Last modification date: 2024-01-24)
Primary citation	Benz, J.,Rufer, A.C.,Huber, S.,Ehler, A.,Hug, M.,Topp, A.,Guba, W.,Hofmann, E.C.,Jagasia, R.,Rodriguez Sarmiento, R.M. Novel beta-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew.Chem.Int.Ed.Engl., 60:5436-5442, 2021 Cited by PubMed: 33238058 DOI: 10.1002/anie.202013890 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation