6T13
CRYSTAL STRUCTURE OF GLUCOCEREBROSIDASE IN COMPLEX WITH A PYRROLOPYRAZINE
Summary for 6T13
Entry DOI | 10.2210/pdb6t13/pdb |
Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (10 entities in total) |
Functional Keywords | gcase, glycosidase, cerezyme, hydrolysis, hydrolase, glycosylceramidase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 243175.56 |
Authors | Benz, J.,Ehler, A.,Hug, M.,Huber, S.,Rufer, A.C.,Guba, W.,Jagasia, R.,Hofmann, E.C.,Rodriguez Sarmiento, R.M. (deposition date: 2019-10-03, release date: 2020-12-23, Last modification date: 2024-01-24) |
Primary citation | Benz, J.,Rufer, A.C.,Huber, S.,Ehler, A.,Hug, M.,Topp, A.,Guba, W.,Hofmann, E.C.,Jagasia, R.,Rodriguez Sarmiento, R.M. Novel beta-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization. Angew.Chem.Int.Ed.Engl., 60:5436-5442, 2021 Cited by PubMed: 33238058DOI: 10.1002/anie.202013890 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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