6T13
CRYSTAL STRUCTURE OF GLUCOCEREBROSIDASE IN COMPLEX WITH A PYRROLOPYRAZINE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004348 | molecular_function | glucosylceramidase activity |
A | 0006665 | biological_process | sphingolipid metabolic process |
B | 0004348 | molecular_function | glucosylceramidase activity |
B | 0006665 | biological_process | sphingolipid metabolic process |
C | 0004348 | molecular_function | glucosylceramidase activity |
C | 0006665 | biological_process | sphingolipid metabolic process |
D | 0004348 | molecular_function | glucosylceramidase activity |
D | 0006665 | biological_process | sphingolipid metabolic process |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:15817452 |
Chain | Residue | Details |
A | GLU235 | |
B | GLU235 | |
C | GLU235 | |
D | GLU235 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:15817452 |
Chain | Residue | Details |
A | GLU340 | |
B | GLU340 | |
C | GLU340 | |
D | GLU340 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12792654, ECO:0000269|PubMed:17139081 |
Chain | Residue | Details |
A | ASN19 | |
B | ASN19 | |
C | ASN19 | |
D | ASN19 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:17139081, ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | ASN59 | |
B | ASN59 | |
C | ASN59 | |
D | ASN59 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:17139081 |
Chain | Residue | Details |
A | ASN146 | |
B | ASN146 | |
C | ASN146 | |
D | ASN146 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | ASN270 | |
B | ASN270 | |
C | ASN270 | |
D | ASN270 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN462 | |
B | ASN462 | |
C | ASN462 | |
D | ASN462 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 764 |
Chain | Residue | Details |
A | GLU235 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
A | GLU340 | covalently attached, nucleofuge, nucleophile |
A | CYS342 | electrostatic stabiliser |
A | ASN370 |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 764 |
Chain | Residue | Details |
B | GLU235 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
B | GLU340 | covalently attached, nucleofuge, nucleophile |
B | CYS342 | electrostatic stabiliser |
B | ASN370 |
site_id | MCSA3 |
Number of Residues | 4 |
Details | M-CSA 764 |
Chain | Residue | Details |
C | GLU235 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
C | GLU340 | covalently attached, nucleofuge, nucleophile |
C | CYS342 | electrostatic stabiliser |
C | ASN370 |
site_id | MCSA4 |
Number of Residues | 4 |
Details | M-CSA 764 |
Chain | Residue | Details |
D | GLU235 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
D | GLU340 | covalently attached, nucleofuge, nucleophile |
D | CYS342 | electrostatic stabiliser |
D | ASN370 |